Misregulation of DNA Methylation Regulators in Cancer

Joyce J. Thompson, Keith D. Robertson

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Epigenetic modifications at the DNA level play a central role in establishing the chromatin state and thereby influencing biological function. Several disorders arise from aberrant epigenetic patterns on DNA, cancer being widely explored as an epigenetic disorder. In fact several cancers are associated with a hypermethylator phenotype, which essentially functions as a ‘driver’ of tumorigenesis. Aberrant DNA methylation patterns arise from disrupting the ‘writers’ or ‘erasers’ of the DNA methylation pathway, coordinately functioning to regulate DNA epigenetic marks. Cancer associated deregulatory mechanisms targeting functional disruption of the molecular components of the DNA methylation pathway, and their contribution to cancer initiation and progression are being increasingly appreciated. Understanding these mechanisms of deregulation is central to identifying new targets for therapeutic intervention, in both cancer prevention and treatment.

Original languageEnglish (US)
Title of host publicationCancer Drug Discovery and Development
PublisherHumana Press Inc.
Pages97-124
Number of pages28
Edition9783319597843
DOIs
StatePublished - 2017

Publication series

NameCancer Drug Discovery and Development
Number9783319597843
Volume0
ISSN (Print)2196-9906
ISSN (Electronic)2196-9914

Keywords

  • DNA methylation pathway
  • DNMT
  • Epimutation
  • Hypermethylator phenotype
  • Oncogenic
  • TET
  • Tumorigenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Drug Discovery

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  • Cite this

    Thompson, J. J., & Robertson, K. D. (2017). Misregulation of DNA Methylation Regulators in Cancer. In Cancer Drug Discovery and Development (9783319597843 ed., pp. 97-124). (Cancer Drug Discovery and Development; Vol. 0, No. 9783319597843). Humana Press Inc.. https://doi.org/10.1007/978-3-319-59786-7_5