Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

Bo Liu, Nicholas C. Nicolaides, Sanford Markowitz, James K.V. Willson, Ramon E. Parsons, Jin Jen, Nickolas Papadopolous, Päivi Peltomäki, Albert de la Chapelle, Stanley R. Hamilton, Kenneth W. Kinzler, Bert Vogelstein

Research output: Contribution to journalArticle

717 Scopus citations

Abstract

Microsatellite instability has been observed in both sporadic and hereditary forms of colorectal cancer. In the hereditary form, this instability is generally due to germline mutations in mismatch repair (MMR) genes. However, only one in ten patients with sporadic tumours exhibiting microsatellite instability had a detectable germline mutation. Moreover, only three of seven sporadic tumour cell lines with microsatellite instability had mutations in a MMR gene, and these mutations could occur somatically. These results demonstrate that tumours can acquire somatic mutations that presumably do not directly affect cell growth but result only in genetic instability. They also suggest that many sporadic tumours with microsatellite instability have alterations in genes other than the four now known to participate in MMR.

Original languageEnglish (US)
Pages (from-to)48-55
Number of pages8
JournalNature Genetics
Volume9
Issue number1
DOIs
StatePublished - Jan 1995

ASJC Scopus subject areas

  • Genetics

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    Liu, B., Nicolaides, N. C., Markowitz, S., Willson, J. K. V., Parsons, R. E., Jen, J., Papadopolous, N., Peltomäki, P., de la Chapelle, A., Hamilton, S. R., Kinzler, K. W., & Vogelstein, B. (1995). Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nature Genetics, 9(1), 48-55. https://doi.org/10.1038/ng0195-48