Mismatch between insulin-mediated glucose uptake and blood flow in the heart of patients with type II diabetes

P. Iozzo, P. Chareonthaitawee, O. Rimoldi, D. Betteridge, P. Camici, E. Ferrannini

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Aims/hypothesis. We investigated the effect of physiological hyperinsulinaemia on global and regional myocardial blood flow and glucose uptake in five patients with Type II (non-insulin-dependent) diabetes mellitus and seven healthy control subjects. Methods. Myocardial blood flow was assessed by positron emission tomography with oxygen-15 labelled water (H215O) either before or after 1 h of euglycaemic hyperinsulinaemia. Myocardial glucose uptake was assessed by positron emission tomography and fluorine-18 labelled fluorodeoxyglucose (18FDG). Results. During hyperinsulinaemia, myocardial blood flow increased from 0.91±0.03 to 1.00±0.03 ml·min-1·g-1 in control subjects (p<0.005) and from 0.81±0.02 to 0.95±0.04 ml·min-1·g-1 in diabetic patients (p<0.0005). Corresponding glucose uptakes were 0.56±0.01 and 0.36±0.02 μmol·min-1·g-1 (p<0.0001), respectively. During hyperinsulinaemia, the regional distribution of myocardial blood flow and glucose uptake showed higher values in the septum and anterolateral wall (short axis) and in the mid-ventricle (long axis) in control subjects, and insulin action was circumscribed to these regions. In diabetic patients, the regional distribution of glucose uptake was similar; however, insulin-induced increase of myocardial blood flow was mainly directed to the postero-inferior areas (short axis) and to the base (long axis) of the heart, thus cancelling the predominance of the anterior wall observed before insulin administration. Conclusion/interpretation. These results provide evidence that insulin-mediated regulation of global myocardial blood flow is preserved in Type II diabetic patients. In contrast, the regional re-distribution of myocardial blood flow induced by insulin is directed to different target areas when compared with healthy subjects, thereby resulting in a mismatch between blood flow and glucose metabolism.

Original languageEnglish (US)
Pages (from-to)1404-1409
Number of pages6
JournalDiabetologia
Volume45
Issue number10
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Blood Glucose
Hyperinsulinism
Insulin
Glucose
Positron-Emission Tomography
Healthy Volunteers
Fluorodeoxyglucose F18
Regional Blood Flow
Type 2 Diabetes Mellitus
Oxygen
Water

Keywords

  • Diabetes
  • Insulin
  • Myocardial glucose metabolism
  • Myocardial perfusion
  • Positron emission tomography

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Iozzo, P., Chareonthaitawee, P., Rimoldi, O., Betteridge, D., Camici, P., & Ferrannini, E. (2002). Mismatch between insulin-mediated glucose uptake and blood flow in the heart of patients with type II diabetes. Diabetologia, 45(10), 1404-1409. https://doi.org/10.1007/s00125-002-0917-3

Mismatch between insulin-mediated glucose uptake and blood flow in the heart of patients with type II diabetes. / Iozzo, P.; Chareonthaitawee, P.; Rimoldi, O.; Betteridge, D.; Camici, P.; Ferrannini, E.

In: Diabetologia, Vol. 45, No. 10, 2002, p. 1404-1409.

Research output: Contribution to journalArticle

Iozzo, P, Chareonthaitawee, P, Rimoldi, O, Betteridge, D, Camici, P & Ferrannini, E 2002, 'Mismatch between insulin-mediated glucose uptake and blood flow in the heart of patients with type II diabetes', Diabetologia, vol. 45, no. 10, pp. 1404-1409. https://doi.org/10.1007/s00125-002-0917-3
Iozzo, P. ; Chareonthaitawee, P. ; Rimoldi, O. ; Betteridge, D. ; Camici, P. ; Ferrannini, E. / Mismatch between insulin-mediated glucose uptake and blood flow in the heart of patients with type II diabetes. In: Diabetologia. 2002 ; Vol. 45, No. 10. pp. 1404-1409.
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AU - Betteridge, D.

AU - Camici, P.

AU - Ferrannini, E.

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N2 - Aims/hypothesis. We investigated the effect of physiological hyperinsulinaemia on global and regional myocardial blood flow and glucose uptake in five patients with Type II (non-insulin-dependent) diabetes mellitus and seven healthy control subjects. Methods. Myocardial blood flow was assessed by positron emission tomography with oxygen-15 labelled water (H215O) either before or after 1 h of euglycaemic hyperinsulinaemia. Myocardial glucose uptake was assessed by positron emission tomography and fluorine-18 labelled fluorodeoxyglucose (18FDG). Results. During hyperinsulinaemia, myocardial blood flow increased from 0.91±0.03 to 1.00±0.03 ml·min-1·g-1 in control subjects (p<0.005) and from 0.81±0.02 to 0.95±0.04 ml·min-1·g-1 in diabetic patients (p<0.0005). Corresponding glucose uptakes were 0.56±0.01 and 0.36±0.02 μmol·min-1·g-1 (p<0.0001), respectively. During hyperinsulinaemia, the regional distribution of myocardial blood flow and glucose uptake showed higher values in the septum and anterolateral wall (short axis) and in the mid-ventricle (long axis) in control subjects, and insulin action was circumscribed to these regions. In diabetic patients, the regional distribution of glucose uptake was similar; however, insulin-induced increase of myocardial blood flow was mainly directed to the postero-inferior areas (short axis) and to the base (long axis) of the heart, thus cancelling the predominance of the anterior wall observed before insulin administration. Conclusion/interpretation. These results provide evidence that insulin-mediated regulation of global myocardial blood flow is preserved in Type II diabetic patients. In contrast, the regional re-distribution of myocardial blood flow induced by insulin is directed to different target areas when compared with healthy subjects, thereby resulting in a mismatch between blood flow and glucose metabolism.

AB - Aims/hypothesis. We investigated the effect of physiological hyperinsulinaemia on global and regional myocardial blood flow and glucose uptake in five patients with Type II (non-insulin-dependent) diabetes mellitus and seven healthy control subjects. Methods. Myocardial blood flow was assessed by positron emission tomography with oxygen-15 labelled water (H215O) either before or after 1 h of euglycaemic hyperinsulinaemia. Myocardial glucose uptake was assessed by positron emission tomography and fluorine-18 labelled fluorodeoxyglucose (18FDG). Results. During hyperinsulinaemia, myocardial blood flow increased from 0.91±0.03 to 1.00±0.03 ml·min-1·g-1 in control subjects (p<0.005) and from 0.81±0.02 to 0.95±0.04 ml·min-1·g-1 in diabetic patients (p<0.0005). Corresponding glucose uptakes were 0.56±0.01 and 0.36±0.02 μmol·min-1·g-1 (p<0.0001), respectively. During hyperinsulinaemia, the regional distribution of myocardial blood flow and glucose uptake showed higher values in the septum and anterolateral wall (short axis) and in the mid-ventricle (long axis) in control subjects, and insulin action was circumscribed to these regions. In diabetic patients, the regional distribution of glucose uptake was similar; however, insulin-induced increase of myocardial blood flow was mainly directed to the postero-inferior areas (short axis) and to the base (long axis) of the heart, thus cancelling the predominance of the anterior wall observed before insulin administration. Conclusion/interpretation. These results provide evidence that insulin-mediated regulation of global myocardial blood flow is preserved in Type II diabetic patients. In contrast, the regional re-distribution of myocardial blood flow induced by insulin is directed to different target areas when compared with healthy subjects, thereby resulting in a mismatch between blood flow and glucose metabolism.

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