MiR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype

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39 Scopus citations

Abstract

Decreased expression of miRNAs of the miR-200 family has been implicated in the growth and metastasis of breast cancer cells. Of this family, miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2, mediators of epithelial- mesenchymal transition. An article in the previous issue of Breast Cancer Research identifies additional targets of miR-200c that link increased cancer cell invasiveness, resistance to apoptosis, and induction of breast cancer stem cell characteristics.

Original languageEnglish (US)
Article number110
JournalBreast Cancer Research
Volume13
Issue number3
DOIs
StatePublished - Jun 10 2011

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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