Minireview: The paired box-8/peroxisome proliferator-activated receptor-γ oncogene in thyroid tumorigenesis

Honey V. Reddi, Bryan McIver, S. K G Grebe, Norman L. Eberhardt

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The American Cancer Society estimates 30,180 new cases of thyroid cancer in the United States in 2006. Of all thyroid cancers, 15-20% are follicular thyroid carcinoma (FTC), making this the second most common thyroid malignancy (after papillary carcinoma). A proportion of FTC has been found to be associated with a chromosomal translocation, t (2, 3)(q13; p25), which fuses the thyroid-specific transcription factor paired box-8 with the peroxisome proliferator-activated receptor-γ nuclear receptor, a ubiquitously expressed transcription factor. This fusion event causes expression of a paired box-8/peroxisome proliferator-activated receptor-γ fusion protein (PPFP). PPFP is detected in approximately 30% of FTC. In this report we review data on the role of PPFP in FTC, its mechanism of oncogenesis, and PPFP targeting as a strategy in thyroid cancer treatment.

Original languageEnglish (US)
Pages (from-to)932-935
Number of pages4
JournalEndocrinology
Volume148
Issue number3
DOIs
StatePublished - Mar 2007

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Peroxisome Proliferator-Activated Receptors
Follicular Adenocarcinoma
Oncogenes
Thyroid Gland
Carcinogenesis
Thyroid Neoplasms
Paired Box Transcription Factors
Genetic Translocation
Proteins
Papillary Carcinoma
Protein Transport
Cytoplasmic and Nuclear Receptors
Transcription Factors
Neoplasms

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Minireview : The paired box-8/peroxisome proliferator-activated receptor-γ oncogene in thyroid tumorigenesis. / Reddi, Honey V.; McIver, Bryan; Grebe, S. K G; Eberhardt, Norman L.

In: Endocrinology, Vol. 148, No. 3, 03.2007, p. 932-935.

Research output: Contribution to journalArticle

Reddi, Honey V. ; McIver, Bryan ; Grebe, S. K G ; Eberhardt, Norman L. / Minireview : The paired box-8/peroxisome proliferator-activated receptor-γ oncogene in thyroid tumorigenesis. In: Endocrinology. 2007 ; Vol. 148, No. 3. pp. 932-935.
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