TY - JOUR
T1 - Minireview
T2 - The paired box-8/peroxisome proliferator-activated receptor-γ oncogene in thyroid tumorigenesis
AU - Reddi, Honey V.
AU - McIver, Bryan
AU - Grebe, Stefan K.G.
AU - Eberhardt, Norman L.
PY - 2007/3
Y1 - 2007/3
N2 - The American Cancer Society estimates 30,180 new cases of thyroid cancer in the United States in 2006. Of all thyroid cancers, 15-20% are follicular thyroid carcinoma (FTC), making this the second most common thyroid malignancy (after papillary carcinoma). A proportion of FTC has been found to be associated with a chromosomal translocation, t (2, 3)(q13; p25), which fuses the thyroid-specific transcription factor paired box-8 with the peroxisome proliferator-activated receptor-γ nuclear receptor, a ubiquitously expressed transcription factor. This fusion event causes expression of a paired box-8/peroxisome proliferator-activated receptor-γ fusion protein (PPFP). PPFP is detected in approximately 30% of FTC. In this report we review data on the role of PPFP in FTC, its mechanism of oncogenesis, and PPFP targeting as a strategy in thyroid cancer treatment.
AB - The American Cancer Society estimates 30,180 new cases of thyroid cancer in the United States in 2006. Of all thyroid cancers, 15-20% are follicular thyroid carcinoma (FTC), making this the second most common thyroid malignancy (after papillary carcinoma). A proportion of FTC has been found to be associated with a chromosomal translocation, t (2, 3)(q13; p25), which fuses the thyroid-specific transcription factor paired box-8 with the peroxisome proliferator-activated receptor-γ nuclear receptor, a ubiquitously expressed transcription factor. This fusion event causes expression of a paired box-8/peroxisome proliferator-activated receptor-γ fusion protein (PPFP). PPFP is detected in approximately 30% of FTC. In this report we review data on the role of PPFP in FTC, its mechanism of oncogenesis, and PPFP targeting as a strategy in thyroid cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=33847057768&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847057768&partnerID=8YFLogxK
U2 - 10.1210/en.2006-0926
DO - 10.1210/en.2006-0926
M3 - Short survey
C2 - 16946003
AN - SCOPUS:33847057768
SN - 0013-7227
VL - 148
SP - 932
EP - 935
JO - Endocrinology
JF - Endocrinology
IS - 3
ER -