Minireview: The paired box-8/peroxisome proliferator-activated receptor-γ oncogene in thyroid tumorigenesis

Honey V. Reddi, Bryan McIver, Stefan K.G. Grebe, Norman L. Eberhardt

Research output: Contribution to journalShort survey

34 Scopus citations

Abstract

The American Cancer Society estimates 30,180 new cases of thyroid cancer in the United States in 2006. Of all thyroid cancers, 15-20% are follicular thyroid carcinoma (FTC), making this the second most common thyroid malignancy (after papillary carcinoma). A proportion of FTC has been found to be associated with a chromosomal translocation, t (2, 3)(q13; p25), which fuses the thyroid-specific transcription factor paired box-8 with the peroxisome proliferator-activated receptor-γ nuclear receptor, a ubiquitously expressed transcription factor. This fusion event causes expression of a paired box-8/peroxisome proliferator-activated receptor-γ fusion protein (PPFP). PPFP is detected in approximately 30% of FTC. In this report we review data on the role of PPFP in FTC, its mechanism of oncogenesis, and PPFP targeting as a strategy in thyroid cancer treatment.

Original languageEnglish (US)
Pages (from-to)932-935
Number of pages4
JournalEndocrinology
Volume148
Issue number3
DOIs
StatePublished - Mar 1 2007

ASJC Scopus subject areas

  • Endocrinology

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