Minimally invasive treatment of a painful osteolytic lumbar lesion secondary to epithelioid hemangioendothelioma

Arjun S. Sebastian, Marcus J. Adair, Jonathan M. Morris, Mustafa H. Khan, Carola A.S. Arndt, Ahmad Nassr

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Study Design Case report. Objective Multifocal epithelioid hemangioendothelioma (EHE) of the spine is a rare disorder. We describe a novel, multimodal treatment of a painful osteolytic lumbar lesion secondary to EHE. The minimally invasive treatment results in an excellent patient outcome with decreased morbidity compared to traditional techniques. Methods A previously healthy young adult presented with a painful osteolytic lesion at the L2 vertebrae. Imaging revealed multifocal spinal lesions consistent with a history of EHE. Core needle biopsy confirmed the diagnosis. Preoperative cryoablation of L2 was followed by a staged surgery, which included a partial L2 corpectomy, tumor resection, bone grafting, and vertebral reconstruction using a minimally invasive technique. This treatment was followed by prolonged therapy with interferon and bisphosphonate. Results At 3.5 years' follow-up, the patient has maintained his vertebral body height, has not required a fusion, and has had no recurrence of disease. Conclusion Multimodal treatment consisting of tumor cryoablation, partial corpectomy, allograft reconstruction of the vertebrae, and adjuvant interferon and bisphosphonate can result in good outcomes for well-contained EHE tumors of the spine.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalGlobal Spine Journal
Volume5
Issue number2
DOIs
StatePublished - Aug 6 2014

Fingerprint

Epithelioid Hemangioendothelioma
Spine
Combined Modality Therapy
Cryosurgery
Diphosphonates
Interferons
Large-Core Needle Biopsy
Neoplasms
Body Height
Bone Transplantation
Therapeutics
Allografts
Young Adult
Morbidity
Recurrence

Keywords

  • cryoablation
  • intravertebral polyethylene mesh bag
  • MIS
  • multifocal spinal epithelioid hemangioendothelioma

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

Minimally invasive treatment of a painful osteolytic lumbar lesion secondary to epithelioid hemangioendothelioma. / Sebastian, Arjun S.; Adair, Marcus J.; Morris, Jonathan M.; Khan, Mustafa H.; Arndt, Carola A.S.; Nassr, Ahmad.

In: Global Spine Journal, Vol. 5, No. 2, 06.08.2014, p. 135-139.

Research output: Contribution to journalArticle

Sebastian, Arjun S. ; Adair, Marcus J. ; Morris, Jonathan M. ; Khan, Mustafa H. ; Arndt, Carola A.S. ; Nassr, Ahmad. / Minimally invasive treatment of a painful osteolytic lumbar lesion secondary to epithelioid hemangioendothelioma. In: Global Spine Journal. 2014 ; Vol. 5, No. 2. pp. 135-139.
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