Minimal-invasive Quantifizierung der myokardialen Mikrozirkulationsfunktion mittels Computertomographie

Die Blutvolumen-Fluss-Beziehung

Translated title of the contribution: Minimally invasive quantitation of myocardial microvascular function using computed tomography: The blood volume-to-flow relationship

S. Möhlenkamp, E. L. Ritman, M. Haude, R. Erbel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The intramyocardial coronary microvasculature has an important role in regulating regional myocardial perfusion. Pathologic alterations of microvascular function may be present in early stages of coronary artery disease, myocardial hypertrophy, cardiomyopathy or systemic diseases such as arterial hypertension and diabetes mellitus. Fast computed tomography permits noninvasive simultaneous quantitation of regional intramyocardial blood volume and myocardial perfusion using indicator dilution principles. Our data indicate that especially the blood volume-to-flow relationship is sensitive enough to characterize and quantitate the functional impact of different pathologies along the coronary tree on microvascular function. This could be demonstrated for 1) acute impairment of microvascular function following coronary microembolization, 2) endothelial dysfunction induced by chronic hypercholesterolemia, 3) chronic epicardial non-significant stenoses, 4) physiologic maturation of the normal microvasculature and 5) quantification of heterogeneity of microvascular function. These findings, the methodological background and the concept itself are presented in this article. Application of the blood volume-to-flow relationship is not limited to fast-CT but may be used in any cross sectional imaging technique, such as MRI or echocardiography, as long as intramyocardial blood volume and perfusion can be quantitated simultaneously. This new noninvasive approach to the quantification of intramyocardial microvascular function may prove a useful adjunct to those imaging techniques that are used to noninvasively quantitate epicardial stenoses or regional wall motion abnormalities.

Original languageGerman
Pages (from-to)514-523
Number of pages10
JournalZeitschrift fur Kardiologie
Volume93
Issue number7
StatePublished - Jul 2004

Fingerprint

Blood Volume
Tomography
Perfusion
Microvessels
Pathologic Constriction
Hypercholesterolemia
Cardiomyopathies
Hypertrophy
Echocardiography
Coronary Artery Disease
Diabetes Mellitus
Pathology
Hypertension

Keywords

  • Blood volume
  • CT
  • Electron beam computed tomography
  • Microcirculation
  • Perfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Minimal-invasive Quantifizierung der myokardialen Mikrozirkulationsfunktion mittels Computertomographie : Die Blutvolumen-Fluss-Beziehung. / Möhlenkamp, S.; Ritman, E. L.; Haude, M.; Erbel, R.

In: Zeitschrift fur Kardiologie, Vol. 93, No. 7, 07.2004, p. 514-523.

Research output: Contribution to journalArticle

@article{31152925f2524f8ba9fd6315f20dfcfd,
title = "Minimal-invasive Quantifizierung der myokardialen Mikrozirkulationsfunktion mittels Computertomographie: Die Blutvolumen-Fluss-Beziehung",
abstract = "The intramyocardial coronary microvasculature has an important role in regulating regional myocardial perfusion. Pathologic alterations of microvascular function may be present in early stages of coronary artery disease, myocardial hypertrophy, cardiomyopathy or systemic diseases such as arterial hypertension and diabetes mellitus. Fast computed tomography permits noninvasive simultaneous quantitation of regional intramyocardial blood volume and myocardial perfusion using indicator dilution principles. Our data indicate that especially the blood volume-to-flow relationship is sensitive enough to characterize and quantitate the functional impact of different pathologies along the coronary tree on microvascular function. This could be demonstrated for 1) acute impairment of microvascular function following coronary microembolization, 2) endothelial dysfunction induced by chronic hypercholesterolemia, 3) chronic epicardial non-significant stenoses, 4) physiologic maturation of the normal microvasculature and 5) quantification of heterogeneity of microvascular function. These findings, the methodological background and the concept itself are presented in this article. Application of the blood volume-to-flow relationship is not limited to fast-CT but may be used in any cross sectional imaging technique, such as MRI or echocardiography, as long as intramyocardial blood volume and perfusion can be quantitated simultaneously. This new noninvasive approach to the quantification of intramyocardial microvascular function may prove a useful adjunct to those imaging techniques that are used to noninvasively quantitate epicardial stenoses or regional wall motion abnormalities.",
keywords = "Blood volume, CT, Electron beam computed tomography, Microcirculation, Perfusion",
author = "S. M{\"o}hlenkamp and Ritman, {E. L.} and M. Haude and R. Erbel",
year = "2004",
month = "7",
language = "German",
volume = "93",
pages = "514--523",
journal = "Clinical Research in Cardiology",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "7",

}

TY - JOUR

T1 - Minimal-invasive Quantifizierung der myokardialen Mikrozirkulationsfunktion mittels Computertomographie

T2 - Die Blutvolumen-Fluss-Beziehung

AU - Möhlenkamp, S.

AU - Ritman, E. L.

AU - Haude, M.

AU - Erbel, R.

PY - 2004/7

Y1 - 2004/7

N2 - The intramyocardial coronary microvasculature has an important role in regulating regional myocardial perfusion. Pathologic alterations of microvascular function may be present in early stages of coronary artery disease, myocardial hypertrophy, cardiomyopathy or systemic diseases such as arterial hypertension and diabetes mellitus. Fast computed tomography permits noninvasive simultaneous quantitation of regional intramyocardial blood volume and myocardial perfusion using indicator dilution principles. Our data indicate that especially the blood volume-to-flow relationship is sensitive enough to characterize and quantitate the functional impact of different pathologies along the coronary tree on microvascular function. This could be demonstrated for 1) acute impairment of microvascular function following coronary microembolization, 2) endothelial dysfunction induced by chronic hypercholesterolemia, 3) chronic epicardial non-significant stenoses, 4) physiologic maturation of the normal microvasculature and 5) quantification of heterogeneity of microvascular function. These findings, the methodological background and the concept itself are presented in this article. Application of the blood volume-to-flow relationship is not limited to fast-CT but may be used in any cross sectional imaging technique, such as MRI or echocardiography, as long as intramyocardial blood volume and perfusion can be quantitated simultaneously. This new noninvasive approach to the quantification of intramyocardial microvascular function may prove a useful adjunct to those imaging techniques that are used to noninvasively quantitate epicardial stenoses or regional wall motion abnormalities.

AB - The intramyocardial coronary microvasculature has an important role in regulating regional myocardial perfusion. Pathologic alterations of microvascular function may be present in early stages of coronary artery disease, myocardial hypertrophy, cardiomyopathy or systemic diseases such as arterial hypertension and diabetes mellitus. Fast computed tomography permits noninvasive simultaneous quantitation of regional intramyocardial blood volume and myocardial perfusion using indicator dilution principles. Our data indicate that especially the blood volume-to-flow relationship is sensitive enough to characterize and quantitate the functional impact of different pathologies along the coronary tree on microvascular function. This could be demonstrated for 1) acute impairment of microvascular function following coronary microembolization, 2) endothelial dysfunction induced by chronic hypercholesterolemia, 3) chronic epicardial non-significant stenoses, 4) physiologic maturation of the normal microvasculature and 5) quantification of heterogeneity of microvascular function. These findings, the methodological background and the concept itself are presented in this article. Application of the blood volume-to-flow relationship is not limited to fast-CT but may be used in any cross sectional imaging technique, such as MRI or echocardiography, as long as intramyocardial blood volume and perfusion can be quantitated simultaneously. This new noninvasive approach to the quantification of intramyocardial microvascular function may prove a useful adjunct to those imaging techniques that are used to noninvasively quantitate epicardial stenoses or regional wall motion abnormalities.

KW - Blood volume

KW - CT

KW - Electron beam computed tomography

KW - Microcirculation

KW - Perfusion

UR - http://www.scopus.com/inward/record.url?scp=3242885314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242885314&partnerID=8YFLogxK

M3 - Article

VL - 93

SP - 514

EP - 523

JO - Clinical Research in Cardiology

JF - Clinical Research in Cardiology

SN - 1861-0684

IS - 7

ER -