TY - JOUR
T1 - Minimally invasive fibrillating mitral valve replacement for patients with advanced cardiomyopathy
T2 - A safe and effective approach to treat a complex problem
AU - Brittain, Evan L.
AU - Goyal, Sandeep K.
AU - Sample, Matthew A.
AU - Leacche, Marzia
AU - Absi, Tarek S.
AU - Papa, Frank
AU - Churchwell, Keith B.
AU - Ball, Stephen
AU - Byrne, John G.
AU - Maltais, Simon
AU - Petracek, Michael R.
AU - Mendes, Lisa
N1 - Publisher Copyright:
© 2014 by The American Association for Thoracic Surgery.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Objective The optimal management of mitral regurgitation (MR) in patients with cardiomyopathy has been controversial. Minimally invasive fibrillating mitral valve replacement (mini-MVR) might limit postoperative morbidity and mortality by minimizing recurrent MR. We hypothesized that mini-MVR with complete chordal sparing would offer low mortality and halt left ventricular (LV) remodeling in patients with severe cardiomyopathy and severe MR.Methods From January 2006 to August 2009, 65 patients with an LV ejection fraction (LVEF) of 35% underwent mini-MVR. The demographic, echocardiographic, and clinical outcomes were analyzed.Results The operative mortality compared with the Society of Thoracic Surgeons-predicted mortality was 6.2% versus 6.6%. It was 5.6% versus 7.4% for patients with an LVEF of ;20% and 8.3% versus 17.9% among patients with a Society of Thoracic Surgeons-predicted mortality of 10%. At a median follow-up of 17 months, no recurrent MR or change in the LV dimensions or LVEF had developed, but the right ventricular systolic pressure had decreased (P =.02). At the first postoperative visit and latest follow-up visit, the New York Heart Association class had decreased from 3.0 ± 0.6 to 1.7 ± 0.7 and 2.0 ± 1.0, respectively (P <.0001 for both). Patients with an LVEF of 20% and LV end-diastolic diameter of 6.5 cm were more likely to meet a composite of death, transplantation, or LV assist device insertion (P =.046).Conclusions Our results have shown that mini-MVR is safe in patients with advanced cardiomyopathy and resulted in no recurrent MR, stabilization of the LVEF and LV dimensions, and a decrease in right ventricular systolic pressure. This mini-MVR technique can be used to address severe MR in patients with advanced cardiomyopathy.
AB - Objective The optimal management of mitral regurgitation (MR) in patients with cardiomyopathy has been controversial. Minimally invasive fibrillating mitral valve replacement (mini-MVR) might limit postoperative morbidity and mortality by minimizing recurrent MR. We hypothesized that mini-MVR with complete chordal sparing would offer low mortality and halt left ventricular (LV) remodeling in patients with severe cardiomyopathy and severe MR.Methods From January 2006 to August 2009, 65 patients with an LV ejection fraction (LVEF) of 35% underwent mini-MVR. The demographic, echocardiographic, and clinical outcomes were analyzed.Results The operative mortality compared with the Society of Thoracic Surgeons-predicted mortality was 6.2% versus 6.6%. It was 5.6% versus 7.4% for patients with an LVEF of ;20% and 8.3% versus 17.9% among patients with a Society of Thoracic Surgeons-predicted mortality of 10%. At a median follow-up of 17 months, no recurrent MR or change in the LV dimensions or LVEF had developed, but the right ventricular systolic pressure had decreased (P =.02). At the first postoperative visit and latest follow-up visit, the New York Heart Association class had decreased from 3.0 ± 0.6 to 1.7 ± 0.7 and 2.0 ± 1.0, respectively (P <.0001 for both). Patients with an LVEF of 20% and LV end-diastolic diameter of 6.5 cm were more likely to meet a composite of death, transplantation, or LV assist device insertion (P =.046).Conclusions Our results have shown that mini-MVR is safe in patients with advanced cardiomyopathy and resulted in no recurrent MR, stabilization of the LVEF and LV dimensions, and a decrease in right ventricular systolic pressure. This mini-MVR technique can be used to address severe MR in patients with advanced cardiomyopathy.
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U2 - 10.1016/j.jtcvs.2013.10.062
DO - 10.1016/j.jtcvs.2013.10.062
M3 - Article
C2 - 24332110
AN - SCOPUS:84911005437
SN - 0022-5223
VL - 148
SP - 2045-2051.e1
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
IS - 5
ER -