Minimally invasive biomarker studies in eosinophilic esophagitis: A systematic review

Brittany T. Hines, Matthew A Rank, Benjamin Wright, Lisa A. Marks, John B. Hagan, Alex Straumann, Matthew Greenhawt, Evan S. Dellon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Eosinophilic esophagitis (EoE) is a chronic, inflammatory disease of the esophagus that currently requires repeated endoscopic biopsies for diagnosis and monitoring because no reliable noninvasive markers have been identified. Objective: To identify promising minimally invasive EoE biomarkers and remaining gaps in biomarker validation. Methods: We performed a systematic review of EMBASE, Ovid MEDLINE, PubMed, and Web of Science from inception to June 6, 2017. Studies were included if patients met the 2007 consensus criteria for EoE diagnosis, a minimally invasive biomarker was assessed, and the study included at least 1 control for comparison. Results: The search identified 2094 studies, with 234 reviewed at full-text level, and 49 included in the analysis (20 adult, 19 pediatric, 7 pediatric and adult, and 3 not stated). Most (26 of 49) were published after 2014. Thirty-five studies included healthy controls, 9 analyzed atopic controls, and 29 compared samples from patients with active and inactive EoE. Minimally invasive biomarkers were obtained from peripheral blood (n = 41 studies), sponge or string samples (n = 3), oral or throat swab secretions (n = 2), breath condensate (n = 2), stool (n = 2), and urine (n = 2). The most commonly reported biomarkers were peripheral blood eosinophils (n = 16), blood and string eosinophil granule proteins (n = 14), and eosinophil surface or intracellular markers (n = 12). EoE biomarkers distinguished active EoE from healthy controls in 23 studies, atopic controls in 2 studies, and inactive EoE controls in 20 studies. Conclusion: Several promising minimally invasive biomarkers for EoE have emerged; however, few are able to differentiate EoE from other atopic diseases.

Original languageEnglish (US)
Pages (from-to)218-228
Number of pages11
JournalAnnals of Allergy, Asthma and Immunology
Volume121
Issue number2
DOIs
StatePublished - Aug 1 2018

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Eosinophilic Esophagitis
Biomarkers
Eosinophils
Eosinophil Granule Proteins
Pediatrics
Porifera
Pharynx
PubMed
MEDLINE
Esophagus
Chronic Disease
Urine
Biopsy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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Minimally invasive biomarker studies in eosinophilic esophagitis : A systematic review. / Hines, Brittany T.; Rank, Matthew A; Wright, Benjamin; Marks, Lisa A.; Hagan, John B.; Straumann, Alex; Greenhawt, Matthew; Dellon, Evan S.

In: Annals of Allergy, Asthma and Immunology, Vol. 121, No. 2, 01.08.2018, p. 218-228.

Research output: Contribution to journalArticle

Hines, Brittany T. ; Rank, Matthew A ; Wright, Benjamin ; Marks, Lisa A. ; Hagan, John B. ; Straumann, Alex ; Greenhawt, Matthew ; Dellon, Evan S. / Minimally invasive biomarker studies in eosinophilic esophagitis : A systematic review. In: Annals of Allergy, Asthma and Immunology. 2018 ; Vol. 121, No. 2. pp. 218-228.
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