Mild cognitive impairment: Is it Alzheimer's disease or not?

Ronald Carl Petersen, David Bennett

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In conclusion, the field of MCI research has been very active in recent years. We contend that MCI represents a transitional state between aging and very early dementia particularly AD. We feel that this is a necessary condition and the current criteria for MCI are useful in characterizing the features of this transition. The research in the field has been somewhat variable but there is a good deal of consistency among various studies attesting to the utility of this construct and its applicability in clinical and research practices. Some of the variability in the literature can be explained by methodological difference including the types of populations recruited and the implementation of given sets of criteria. We agree that some, perhaps many persons with MCI are expressing the early pathology of AD. But MCI is considerably more variable than just a pre-AD, and any slowly progressive condition that develops gradually over many years is likely to have a prodrome in which it can be documented in a milder form that does not meet criteria for the clinically-obvious syndrome.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalJournal of Alzheimer's Disease
Volume7
Issue number3
StatePublished - 2005

Fingerprint

Alzheimer Disease
Research
Dementia
Pathology
Population
Cognitive Dysfunction

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Mild cognitive impairment : Is it Alzheimer's disease or not? / Petersen, Ronald Carl; Bennett, David.

In: Journal of Alzheimer's Disease, Vol. 7, No. 3, 2005, p. 241-245.

Research output: Contribution to journalArticle

@article{01d2ca56e7c4443a879b369c0d0ae30c,
title = "Mild cognitive impairment: Is it Alzheimer's disease or not?",
abstract = "In conclusion, the field of MCI research has been very active in recent years. We contend that MCI represents a transitional state between aging and very early dementia particularly AD. We feel that this is a necessary condition and the current criteria for MCI are useful in characterizing the features of this transition. The research in the field has been somewhat variable but there is a good deal of consistency among various studies attesting to the utility of this construct and its applicability in clinical and research practices. Some of the variability in the literature can be explained by methodological difference including the types of populations recruited and the implementation of given sets of criteria. We agree that some, perhaps many persons with MCI are expressing the early pathology of AD. But MCI is considerably more variable than just a pre-AD, and any slowly progressive condition that develops gradually over many years is likely to have a prodrome in which it can be documented in a milder form that does not meet criteria for the clinically-obvious syndrome.",
author = "Petersen, {Ronald Carl} and David Bennett",
year = "2005",
language = "English (US)",
volume = "7",
pages = "241--245",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "3",

}

TY - JOUR

T1 - Mild cognitive impairment

T2 - Is it Alzheimer's disease or not?

AU - Petersen, Ronald Carl

AU - Bennett, David

PY - 2005

Y1 - 2005

N2 - In conclusion, the field of MCI research has been very active in recent years. We contend that MCI represents a transitional state between aging and very early dementia particularly AD. We feel that this is a necessary condition and the current criteria for MCI are useful in characterizing the features of this transition. The research in the field has been somewhat variable but there is a good deal of consistency among various studies attesting to the utility of this construct and its applicability in clinical and research practices. Some of the variability in the literature can be explained by methodological difference including the types of populations recruited and the implementation of given sets of criteria. We agree that some, perhaps many persons with MCI are expressing the early pathology of AD. But MCI is considerably more variable than just a pre-AD, and any slowly progressive condition that develops gradually over many years is likely to have a prodrome in which it can be documented in a milder form that does not meet criteria for the clinically-obvious syndrome.

AB - In conclusion, the field of MCI research has been very active in recent years. We contend that MCI represents a transitional state between aging and very early dementia particularly AD. We feel that this is a necessary condition and the current criteria for MCI are useful in characterizing the features of this transition. The research in the field has been somewhat variable but there is a good deal of consistency among various studies attesting to the utility of this construct and its applicability in clinical and research practices. Some of the variability in the literature can be explained by methodological difference including the types of populations recruited and the implementation of given sets of criteria. We agree that some, perhaps many persons with MCI are expressing the early pathology of AD. But MCI is considerably more variable than just a pre-AD, and any slowly progressive condition that develops gradually over many years is likely to have a prodrome in which it can be documented in a milder form that does not meet criteria for the clinically-obvious syndrome.

UR - http://www.scopus.com/inward/record.url?scp=21444431843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21444431843&partnerID=8YFLogxK

M3 - Article

C2 - 16006668

AN - SCOPUS:21444431843

VL - 7

SP - 241

EP - 245

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 3

ER -