TY - JOUR
T1 - Mild cognitive impairment is associated with white matter integrity changes in late-myelinating regions within the corpus callosum
AU - Stricker, Nikki H.
AU - Salat, David H.
AU - Kuhn, Taylor P.
AU - Foley, Jessica M.
AU - Price, Jenessa S.
AU - Westlye, Lars T.
AU - Esterman, Michael S.
AU - McGlinchey, Regina E.
AU - Milberg, William P.
AU - Leritz, Elizabeth C.
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Department of Veterans Affairs, Veterans Health Administration, VISN 1 Career Development Award, and the Gilbert Foundation/AFAR. This work was also supported by the Medical Research Service VA Merit Review Awards, Veterans Affairs Clinical Science R&D Career Development Award (1IK2CX000706-01A2), the National Institute of Neurologic Disorders and Stroke (grant number K23NS062148); the National Institute of Nursing Research (grant number R01NR010827), the National Institute on Aging (grant numbers P60AG08812, P01AG004390); the Research Council of Norway (204966/F20), and by the National Institute on Drug Abuse (2T32DA015036).
Publisher Copyright:
© The Author(s) 2015.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Degenerative brain changes in Alzheimer's disease may occur in reverse order of normal brain development based on the retrogenesis model. This study tested whether evidence of reverse myelination was observed in mild cognitive impairment (MCI) using a data-driven analytic approach based on life span developmental data. Whole-brain high-resolution diffusion tensor imaging scans were obtained for 31 patients with MCI and 79 demographically matched healthy older adults. Comparisons across corpus callosum (CC) regions of interest (ROIs) showed decreased fractional anisotropy (FA) in the body but not in the genu or splenium; early-, middle-, and late-myelinating ROIs restricted to the CC revealed decreased FA in late- but not early- or middle-myelinating ROIs. Voxelwise group differences revealed areas of lower FA in MCI, but whole-brain differences were equally distributed across early-, middle-, and late-myelinating regions. Overall, results within the CC support the retrogenesis model, although caution is needed when generalizing these results beyond the CC.
AB - Degenerative brain changes in Alzheimer's disease may occur in reverse order of normal brain development based on the retrogenesis model. This study tested whether evidence of reverse myelination was observed in mild cognitive impairment (MCI) using a data-driven analytic approach based on life span developmental data. Whole-brain high-resolution diffusion tensor imaging scans were obtained for 31 patients with MCI and 79 demographically matched healthy older adults. Comparisons across corpus callosum (CC) regions of interest (ROIs) showed decreased fractional anisotropy (FA) in the body but not in the genu or splenium; early-, middle-, and late-myelinating ROIs restricted to the CC revealed decreased FA in late- but not early- or middle-myelinating ROIs. Voxelwise group differences revealed areas of lower FA in MCI, but whole-brain differences were equally distributed across early-, middle-, and late-myelinating regions. Overall, results within the CC support the retrogenesis model, although caution is needed when generalizing these results beyond the CC.
KW - Alzheimer's disease
KW - corpus callosum
KW - diffusion tensor imaging
KW - magnetic resonance imaging
KW - mild cognitive impairment
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U2 - 10.1177/1533317515578257
DO - 10.1177/1533317515578257
M3 - Article
C2 - 25904759
AN - SCOPUS:84954289594
SN - 1533-3175
VL - 31
SP - 68
EP - 75
JO - American Journal of Alzheimer's Disease and other Dementias
JF - American Journal of Alzheimer's Disease and other Dementias
IS - 1
ER -