Mild cognitive impairment: Current research and clinical implications

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Mild cognitive impairment refers to the transitional state between the cognitive changes of normal aging and the fully developed clinical features of dementia. This topic has received a great deal of attention in the literature in recent years and is being proposed for clinical applications as well. Clinical guidelines, including the original memory-focused criteria and the more recent broadly defined set of criteria, will be presented. The clinical outcome of individuals with mild cognitive impairment will be discussed and several explanations for variability in the literature will be considered. Predictors of progression, including genetic, neuroimaging, biomarker, and clinical characteristics, will be presented, as will the controversies regarding the underlying neuropathology of mild cognitive impairment. The recently completed mild cognitive impairment clinical trials will be discussed and the lessons learned from them translated into recommendations for future investigations. Finally, the clinical utility of mild cognitive impairment, its incorporation into clinical practice, and directions for future research will be proposed.

Original languageEnglish (US)
Pages (from-to)22-31
Number of pages10
JournalSeminars in Neurology
Volume27
Issue number1
DOIs
StatePublished - Feb 2007

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Research
Neuroimaging
Dementia
Biomarkers
Cognitive Dysfunction
Clinical Trials
Guidelines
Neuropathology
Direction compound

Keywords

  • Alzheimer's disease
  • Memory
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Mild cognitive impairment : Current research and clinical implications. / Petersen, Ronald Carl.

In: Seminars in Neurology, Vol. 27, No. 1, 02.2007, p. 22-31.

Research output: Contribution to journalArticle

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