TY - JOUR
T1 - Mild cognitive impairment clinical trials
AU - Petersen, Ronald C.
N1 - Funding Information:
I would like to thank Ms. Donna Asleson for her expert secretarial assistance with the manuscript. This work was supported by grants from the National Institute on Aging (AG 06786, AG 1657, AG 10483).
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2003/8
Y1 - 2003/8
N2 - Most investigators believe that by the time the clinical diagnosis of Alzheimer's disease has been made, sufficient neuronal damage has taken place in the brain to make reversal of the condition unlikely. Prevention would be a more appealing strategy, but the challenges of conducting true primary prevention trials in asymptomatic persons are formidable. The duration and expense of these types of trial make them unappealing. Large numbers of subjects would need to be followed for many years, and without a promising therapeutic agent, this approach would be risky. Hence, the concept of secondary prevention treatment trials involving minimally symptomatic individuals, such as persons with mild cognitive impairment (MCI) - a transitional stage between normal ageing and very early Alzheimer's disease - has evolved and seems more promising. This concept has led to the emergence of a number of clinical trials for MCI, which are discussed here.
AB - Most investigators believe that by the time the clinical diagnosis of Alzheimer's disease has been made, sufficient neuronal damage has taken place in the brain to make reversal of the condition unlikely. Prevention would be a more appealing strategy, but the challenges of conducting true primary prevention trials in asymptomatic persons are formidable. The duration and expense of these types of trial make them unappealing. Large numbers of subjects would need to be followed for many years, and without a promising therapeutic agent, this approach would be risky. Hence, the concept of secondary prevention treatment trials involving minimally symptomatic individuals, such as persons with mild cognitive impairment (MCI) - a transitional stage between normal ageing and very early Alzheimer's disease - has evolved and seems more promising. This concept has led to the emergence of a number of clinical trials for MCI, which are discussed here.
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U2 - 10.1038/nrd1155
DO - 10.1038/nrd1155
M3 - Review article
C2 - 12904814
AN - SCOPUS:0042067944
SN - 1474-1776
VL - 2
SP - 646
EP - 653
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
IS - 8
ER -