Mild cognitive impairment and Alzheimer disease: Regional diffusivity of water

K. Kantarci, Jr Jack, Cheng Xu Yue Cheng Xu, N. G. Campeau, P. C. O'Brien, G. E. Smith, R. J. Ivnik, B. F. Boeve, E. Kokmen, E. G. Tangalos, R. C. Petersen

Research output: Contribution to journalArticle

287 Scopus citations


PURPOSE: To compare the regional diffusivity of water in the brains of normally aging elderly people patients with mild cognitive impairment (MCI) or Alzheimer disease. MATERIALS METHODS: Magnetic resonance images were obtained in 21 patients with Alzheimer disease, 19 patients with MCI 55 normally aging elderly control subjects without evidence of cognitive impairment. Regions of interest were drawn to compare the apparent diffusion coefficient (ADC) the anisotropy index (AI) in frontal, parietal, temporal, occipital, anterior, posterior cingulate white matter (WM), and the thalami and hippocampi. RESULTS: Hippocampal ADC was higher in MCI Alzheimer disease patients than in control subjects. ADC of the temporal stem posterior cingulate, occipital, and parietal WM was higher in Alzheimer disease patients than in control subjects. Except for occipital AI, which was lower in MCI patients than in control subjects, there were no differences in AI among the three groups for any of the regions. CONCLUSION: Hippocampal ADC was significantly different between control subjects MCI patients many of whom likely have preclinical Alzheimer disease. Elevation in hippocampal ADC may reflect early ultrastructural changes in the progression of Alzheimer disease.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
Issue number1
StatePublished - 2001


  • Alzheimer disease
  • Brain, MR,
  • Hippocampus
  • Magnetic resonance (MR), diffusion study
  • Magnetic resonance (MR),tissue characterization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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