Mild cognitive impairment

Serge Gauthier, Barry Reisberg, Michael Zaudig, Ronald Carl Petersen, Karen Ritchie, Karl Broich, Sylvie Belleville, Henry Brodaty, David Bennett, Howard Chertkow, Jeffrey L. Cummings, Mony de Leon, Howard Feldman, Mary Ganguli, Harald Hampel, Philip Scheltens, Mary C. Tierney, Peter Whitehouse, Bengt Winblad

Research output: Contribution to journalArticle

1413 Scopus citations

Abstract

Mild cognitive impairment is a syndrome defined as cognitive decline greater than expected for an individual's age and education level but that does not interfere notably with activities of daily life. Prevalence in population-based epidemiological studies ranges from 3% to 19% in adults older than 65 years. Some people with mild cognitive impairment seem to remain stable or return to normal over time, but more than half progress to dementia within 5 years. Mild cognitive impairment can thus be regarded as a risk state for dementia, and its identification could lead to secondary prevention by controlling risk factors such as systolic hypertension. The amnestic subtype of mild cognitive impairment has a high risk of progression to Alzheimer's disease, and it could constitute a prodromal stage of this disorder. Other definitions and subtypes of mild cognitive impairment need to be studied as potential prodromes of Alzheimer's disease and other types of dementia.

Original languageEnglish (US)
Pages (from-to)1262-1270
Number of pages9
JournalLancet
Volume367
Issue number9518
DOIs
StatePublished - Apr 15 2006

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gauthier, S., Reisberg, B., Zaudig, M., Petersen, R. C., Ritchie, K., Broich, K., Belleville, S., Brodaty, H., Bennett, D., Chertkow, H., Cummings, J. L., de Leon, M., Feldman, H., Ganguli, M., Hampel, H., Scheltens, P., Tierney, M. C., Whitehouse, P., & Winblad, B. (2006). Mild cognitive impairment. Lancet, 367(9518), 1262-1270. https://doi.org/10.1016/S0140-6736(06)68542-5