TY - JOUR
T1 - Migration of Lymphocytes Sensitized against Syngeneic and Allogeneic Spinal Cord after Infusion into Susceptible and Resistant Syngeneic and Semi‐Allogeneic Hosts
AU - CUNNINGHAM, J.
AU - McCULLAGH, P.
PY - 1981/4
Y1 - 1981/4
N2 - Lymphocytes from rats that had been sensitized against spinal cord were infused into unsensitized hosts, and the ability of cells subsequently recovered from the thoracic duct lymph of these recipients to mount anti‐neural responses was tested. Lymph from normal recipients frequently contained reactive lymphocytes during the 4 days following infusion of sensitized cells, whereas cells that had been recovered from transfused rats, resistant to encephalomyelitis as a result of neonatal treatment, were almost invariably bereft of activity. If lymphocytes reactive against allogeneic neural cells were passaged through F1 hybrids of the lymphocyte and sensitizing allogeneic tissue strains, loss or retention of their ability to attack allogeneic neural cells was determined by the method of sensitization of the original lymphocyte donor.
AB - Lymphocytes from rats that had been sensitized against spinal cord were infused into unsensitized hosts, and the ability of cells subsequently recovered from the thoracic duct lymph of these recipients to mount anti‐neural responses was tested. Lymph from normal recipients frequently contained reactive lymphocytes during the 4 days following infusion of sensitized cells, whereas cells that had been recovered from transfused rats, resistant to encephalomyelitis as a result of neonatal treatment, were almost invariably bereft of activity. If lymphocytes reactive against allogeneic neural cells were passaged through F1 hybrids of the lymphocyte and sensitizing allogeneic tissue strains, loss or retention of their ability to attack allogeneic neural cells was determined by the method of sensitization of the original lymphocyte donor.
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U2 - 10.1111/j.1365-3083.1981.tb00142.x
DO - 10.1111/j.1365-3083.1981.tb00142.x
M3 - Article
C2 - 6171026
AN - SCOPUS:0019510410
SN - 0300-9475
VL - 13
SP - 335
EP - 341
JO - Scandinavian Journal of Immunology
JF - Scandinavian Journal of Immunology
IS - 4
ER -