TY - JOUR
T1 - Migraine
T2 - integrated approaches to clinical management and emerging treatments
AU - Ashina, Messoud
AU - Buse, Dawn C.
AU - Ashina, Håkan
AU - Pozo-Rosich, Patricia
AU - Peres, Mario F.P.
AU - Lee, Mi Ji
AU - Terwindt, Gisela M.
AU - Halker Singh, Rashmi
AU - Tassorelli, Cristina
AU - Do, Thien Phu
AU - Mitsikostas, Dimos D.
AU - Dodick, David W.
N1 - Funding Information:
MA is a consultant, speaker, or scientific advisor for AbbVie, Allergan, Amgen, Alder, Biohaven, Eli Lilly, Lundbeck, Novartis, and Teva, and primary investigator for Alder, Amgen, Allergan, Eli Lilly, Lundbeck, Novartis, and Teva trials. MA has no ownership interest and does not own stocks of any pharmaceutical company. MA serves as associate editor of Cephalalgia and associate editor of the Journal of Headache and Pain. MA is president of the International Headache Society. DCB has served as a consultant to and received research funding from Amgen–Novartis, Allergan, Avanir, Biohaven, Eli Lilly, Promius–Dr Reddy's, and Teva. DCB is on the editorial board of Current Pain and Headache Reports. PP-R has received honoraria for participation in clinical trials and contribution to advisory boards or medical education from Allergan, Almirall, Amgen, Biohaven, Chiesi, Electrocore, Eli Lilly, Medscape, Novartis, and Teva. PP-R's headache research is supported by La Caixa Foundation, AGAUR, Instituto Investigacion Carlos III, Migraine Research Foundation, and PERIS. MFPP reports grants from Fapesp and CNPq, and personal fees from Allergan, Eurofarma, Eli Lilly, Libbs, Novartis, Pfizer, and Teva, during the conduct of the study. MJL reports grants from the National Research Foundation of Korea, Korean Society of Neurosonology, and Yuhan Company. MJL is a consultant, speaker, or scientific advisor for Eli Lilly and has received speaker honoraria from Sanofi–Aventis and YuYu Pharma, outside the submitted work. MJL serves as junior editor of Cephalalgia. GMT reports grants or consultancy support from Novartis, Lilly, Teva, and Allergan, and independent support from the Dutch Research Council, National Institutes of Health, European Community, Dutch Heart Foundation, and Dutch Brain Foundation. RHS reports personal fees from Impel, Teva, BioHaven Pharmaceuticals, and Supernus Pharmaceuticals, and grants from Amgen and Eli Lilly. CT has participated in advisory boards for Allergan, ElectroCore, Eli Lilly, Novartis and Teva, has lectured at symposia sponsored by Allergan, Eli Lilly, Novartis, and TEVA, and is principal investigator or collaborator in clinical trials sponsored by Alder, Eli-Lilly, IBSA, Novartis, and Teva. CT has also received research grants from the European Commission, the Italian Ministry of Health, the Italian Ministry of University, and the Migraine Research Foundation. DDM reports grants and personal fees from Cefaly, Electrocore, Eli Lily, Novartis, Merz, Teva, Specifar, Amgen, Biogen, and Genesis Pharma. DWD reports personal fees from Allergan, Amgen, Alder, Arteaus, Pfizer, Colucid, Merck, NuPathe, Eli Lilly Autonomic Technologies, Praxis, Cerecin, CTRLM, Cooltech, XoC, Pieris, Revance, Equinox, GSK, Linpharma, AEON, Ethicon, Zogenix, Supernus, Labrys, Boston Scientific, Medtronic, St Jude, Bristol-Myers Squibb, Lundbeck, Impax, MAP BioPharma, electroCore, Tonix, Novartis, Teva, Alcobra, Zosano, ZP Opco, Insys, Ispen, Acorda, eNeura, Charleston Laboratories, Gore, Biohaven, Biocentric, Magellan, Foresight, IntraMed, SAGE Publishing, Oxford University Press, American Academy of Neurology, UptoDate, Theranica, Decision Resources, Xenon, Dr Reddy's–Promius Pharma, Vedanta, CC Ford West Group, Foresight, Wolters Kluwer Health, Wiley Blackwell, Axsome, Neurolief, Satsuma, and Impel, outside the submitted work. DWD reports personal fees and non-financial support from West Virginia University Foundation, Canadian Headache Society, Healthlogix, Universal Meeting Management, WebMD/Medscape, Oregon Health Science Center, Albert Einstein University, University of Toronto, Synergy, MedNet, Peer View Institute for Medical Education, Medicom, Medlogix, Chameleon Communications, Academy for Continued Healthcare Learning, Haymarket Medical Education, Global Scientific Communications, Miller Medical, MeetingLogiX, University of British Columbia, University of Southern California, University of California (Los Angeles), American Academy of Neurology, and Canadian Headache Society, outside the submitted work. DWD reports options from Epien, GBS/Nocira, Second Opinion Health, Healint, NeuroAssessment Systems, Myndshft, King-Devick Technologies, Aural Analytics, and Ontologics, outside the submitted work. DWD reports non-financial support from Starr Clinical, International Headache Society, American Headache Society, American Brain Foundation, and American Migraine Foundation. DWD has an issued patent entitled Botulinum Toxin Dosage Regimen for Chronic Migraine Prophylaxis (patent number 17189376.1-1466:v). All other authors declare no competing interests.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/4/17
Y1 - 2021/4/17
N2 - Migraine is a highly disabling neurological disorder that directly affects more than 1 billion individuals worldwide. Available treatment options differ between countries and include acute, preventive, and non-pharmacological therapies. Because of major progress in the understanding of migraine pathogenesis, novel mechanism-based medications have emerged and expanded the armamentarium of treatments. We provide a comprehensive overview of the current standard of care that will enable informed clinical management. First, we discuss the efficacy, tolerability, and safety profile of various pharmacological therapies for acute and preventive treatment of migraine. Second, we review the current knowledge on non-pharmacological therapies, such as neuromodulation and biobehavioural approaches, which can be used for a multidisciplinary approach to clinical management. Third, we emphasise that any effective treatment strategy starts with building a therapeutic plan tailored to individual clinical characteristics, preferences, and needs. Finally, we explore the outlook of emerging mechanism-based treatments that could address unmet challenges in clinical management of migraine.
AB - Migraine is a highly disabling neurological disorder that directly affects more than 1 billion individuals worldwide. Available treatment options differ between countries and include acute, preventive, and non-pharmacological therapies. Because of major progress in the understanding of migraine pathogenesis, novel mechanism-based medications have emerged and expanded the armamentarium of treatments. We provide a comprehensive overview of the current standard of care that will enable informed clinical management. First, we discuss the efficacy, tolerability, and safety profile of various pharmacological therapies for acute and preventive treatment of migraine. Second, we review the current knowledge on non-pharmacological therapies, such as neuromodulation and biobehavioural approaches, which can be used for a multidisciplinary approach to clinical management. Third, we emphasise that any effective treatment strategy starts with building a therapeutic plan tailored to individual clinical characteristics, preferences, and needs. Finally, we explore the outlook of emerging mechanism-based treatments that could address unmet challenges in clinical management of migraine.
UR - http://www.scopus.com/inward/record.url?scp=85103990856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85103990856&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(20)32342-4
DO - 10.1016/S0140-6736(20)32342-4
M3 - Review article
C2 - 33773612
AN - SCOPUS:85103990856
VL - 397
SP - 1505
EP - 1518
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 10283
ER -