Abstract
Introduction: The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood. Methods: In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45–64 years. In 2011–2013, 20–25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM. Results: In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late-life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model. Discussion: Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.
| Original language | English (US) |
|---|---|
| Journal | Alzheimer's and Dementia |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- APOE
- Cognition
- Dementia
- Diabetes
- Epidemiology
- Hypertension
- Mild cognitive impairment
- Prevalence
ASJC Scopus subject areas
- Epidemiology
- Health Policy
- Developmental Neuroscience
- Clinical Neurology
- Geriatrics and Gerontology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
Cite this
Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life : The Atherosclerosis Risk in Communities Study. / Knopman, David S; Gottesman, Rebecca F.; Sharrett, A. Richey; Tapia, Amanda L.; DavisThomas, Sonia; Windham, B. Gwen; Coker, Laura; Schneider, Andrea L.C.; Alonso, Alvaro; Coresh, Josef; Albert, Marilyn S.; Mosley, Thomas H.
In: Alzheimer's and Dementia, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life
T2 - The Atherosclerosis Risk in Communities Study
AU - Knopman, David S
AU - Gottesman, Rebecca F.
AU - Sharrett, A. Richey
AU - Tapia, Amanda L.
AU - DavisThomas, Sonia
AU - Windham, B. Gwen
AU - Coker, Laura
AU - Schneider, Andrea L.C.
AU - Alonso, Alvaro
AU - Coresh, Josef
AU - Albert, Marilyn S.
AU - Mosley, Thomas H.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Introduction: The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood. Methods: In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45–64 years. In 2011–2013, 20–25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM. Results: In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late-life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model. Discussion: Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.
AB - Introduction: The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood. Methods: In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45–64 years. In 2011–2013, 20–25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM. Results: In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late-life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model. Discussion: Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.
KW - APOE
KW - Cognition
KW - Dementia
KW - Diabetes
KW - Epidemiology
KW - Hypertension
KW - Mild cognitive impairment
KW - Prevalence
UR - http://www.scopus.com/inward/record.url?scp=85049300280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049300280&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2018.03.011
DO - 10.1016/j.jalz.2018.03.011
M3 - Article
C2 - 29763593
AN - SCOPUS:85049300280
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
ER -