Mid-regional pro-adrenomedullin is associated with pulse pressure, left ventricular mass, and albuminuria in african americans with hypertension

Malik A. Al-Omari, Mahyar Khaleghi, Thomas H. Mosley, Stephen T Turner, Nils G. Morgenthaler, Joachim Struck, Andreas Bergmann, Iftikhar Jan Kullo

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

BackgroundAfrican Americans with hypertension are prone to target-organ damage and adverse cardiovascular events. Biomarkers for early detection of target-organ damage in this ethnic group are needed. Adrenomedullin (ADM) is a circulating vasoactive peptide with vasodilatory and antiproliferative effects that has been reported to be elevated in adults with hypertension.MethodsWe investigated the associations of plasma levels of mid-regional pro-ADM (MR-proADM) with pulse pressure, left ventricular mass (LVM), and albuminuria in 1,034 African-American adults (65 9 years, 72% women) with hypertension. MR-proADM was measured by an immunoluminometric assay, LVM was assessed by 2-dimensional echocardiography, and albuminuria was assessed by urine albumin:creatinine ratio (UACR). Multivariable regression analyses were used to assess whether plasma MR-proADM was independently associated with pulse pressure, LVM indexed by height to the power 2.7 (LVMi), and UACR.ResultsPlasma MR-proADM was significantly correlated (P < 0.001) with pulse pressure, LVMi, and UACR. In separate multivariable linear regression models that adjusted for age and sex, log MR-proADM was associated with greater pulse pressure (P = 0.007), log LVMi (P = 0.001), and log (UACR1) (P< 0.0001). After additional adjustment for body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, smoking history, diabetes, estimated glomerular filtration rate (eGFR), history of myocardial infarction (MI) or stroke, and medication use, log MR-proADM remained significantly associated with greater pulse pressure (P = 0.001), log LVMi (P = 0.029), and log (UACR1) (P = 0.002).ConclusionsIn African-American adults with hypertension, plasma MR-proADM is independently associated with pulse pressure, LVMi, and albuminuria and is a potential biomarker for target organ damage.

Original languageEnglish (US)
Pages (from-to)860-866
Number of pages7
JournalAmerican Journal of Hypertension
Volume22
Issue number8
DOIs
StatePublished - Aug 2009

Fingerprint

Adrenomedullin
Albuminuria
African Americans
Blood Pressure
Hypertension
Albumins
Creatinine
Urine
Linear Models
Biomarkers
Glomerular Filtration Rate
Ethnic Groups
HDL Cholesterol
Echocardiography
Body Mass Index
Smoking
History
Stroke
Myocardial Infarction
Regression Analysis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Mid-regional pro-adrenomedullin is associated with pulse pressure, left ventricular mass, and albuminuria in african americans with hypertension. / Al-Omari, Malik A.; Khaleghi, Mahyar; Mosley, Thomas H.; Turner, Stephen T; Morgenthaler, Nils G.; Struck, Joachim; Bergmann, Andreas; Kullo, Iftikhar Jan.

In: American Journal of Hypertension, Vol. 22, No. 8, 08.2009, p. 860-866.

Research output: Contribution to journalArticle

Al-Omari, Malik A. ; Khaleghi, Mahyar ; Mosley, Thomas H. ; Turner, Stephen T ; Morgenthaler, Nils G. ; Struck, Joachim ; Bergmann, Andreas ; Kullo, Iftikhar Jan. / Mid-regional pro-adrenomedullin is associated with pulse pressure, left ventricular mass, and albuminuria in african americans with hypertension. In: American Journal of Hypertension. 2009 ; Vol. 22, No. 8. pp. 860-866.
@article{740adc39f7f94f3e9bfe55a2b32733e1,
title = "Mid-regional pro-adrenomedullin is associated with pulse pressure, left ventricular mass, and albuminuria in african americans with hypertension",
abstract = "BackgroundAfrican Americans with hypertension are prone to target-organ damage and adverse cardiovascular events. Biomarkers for early detection of target-organ damage in this ethnic group are needed. Adrenomedullin (ADM) is a circulating vasoactive peptide with vasodilatory and antiproliferative effects that has been reported to be elevated in adults with hypertension.MethodsWe investigated the associations of plasma levels of mid-regional pro-ADM (MR-proADM) with pulse pressure, left ventricular mass (LVM), and albuminuria in 1,034 African-American adults (65 9 years, 72{\%} women) with hypertension. MR-proADM was measured by an immunoluminometric assay, LVM was assessed by 2-dimensional echocardiography, and albuminuria was assessed by urine albumin:creatinine ratio (UACR). Multivariable regression analyses were used to assess whether plasma MR-proADM was independently associated with pulse pressure, LVM indexed by height to the power 2.7 (LVMi), and UACR.ResultsPlasma MR-proADM was significantly correlated (P < 0.001) with pulse pressure, LVMi, and UACR. In separate multivariable linear regression models that adjusted for age and sex, log MR-proADM was associated with greater pulse pressure (P = 0.007), log LVMi (P = 0.001), and log (UACR1) (P< 0.0001). After additional adjustment for body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, smoking history, diabetes, estimated glomerular filtration rate (eGFR), history of myocardial infarction (MI) or stroke, and medication use, log MR-proADM remained significantly associated with greater pulse pressure (P = 0.001), log LVMi (P = 0.029), and log (UACR1) (P = 0.002).ConclusionsIn African-American adults with hypertension, plasma MR-proADM is independently associated with pulse pressure, LVMi, and albuminuria and is a potential biomarker for target organ damage.",
author = "Al-Omari, {Malik A.} and Mahyar Khaleghi and Mosley, {Thomas H.} and Turner, {Stephen T} and Morgenthaler, {Nils G.} and Joachim Struck and Andreas Bergmann and Kullo, {Iftikhar Jan}",
year = "2009",
month = "8",
doi = "10.1038/ajh.2009.82",
language = "English (US)",
volume = "22",
pages = "860--866",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Mid-regional pro-adrenomedullin is associated with pulse pressure, left ventricular mass, and albuminuria in african americans with hypertension

AU - Al-Omari, Malik A.

AU - Khaleghi, Mahyar

AU - Mosley, Thomas H.

AU - Turner, Stephen T

AU - Morgenthaler, Nils G.

AU - Struck, Joachim

AU - Bergmann, Andreas

AU - Kullo, Iftikhar Jan

PY - 2009/8

Y1 - 2009/8

N2 - BackgroundAfrican Americans with hypertension are prone to target-organ damage and adverse cardiovascular events. Biomarkers for early detection of target-organ damage in this ethnic group are needed. Adrenomedullin (ADM) is a circulating vasoactive peptide with vasodilatory and antiproliferative effects that has been reported to be elevated in adults with hypertension.MethodsWe investigated the associations of plasma levels of mid-regional pro-ADM (MR-proADM) with pulse pressure, left ventricular mass (LVM), and albuminuria in 1,034 African-American adults (65 9 years, 72% women) with hypertension. MR-proADM was measured by an immunoluminometric assay, LVM was assessed by 2-dimensional echocardiography, and albuminuria was assessed by urine albumin:creatinine ratio (UACR). Multivariable regression analyses were used to assess whether plasma MR-proADM was independently associated with pulse pressure, LVM indexed by height to the power 2.7 (LVMi), and UACR.ResultsPlasma MR-proADM was significantly correlated (P < 0.001) with pulse pressure, LVMi, and UACR. In separate multivariable linear regression models that adjusted for age and sex, log MR-proADM was associated with greater pulse pressure (P = 0.007), log LVMi (P = 0.001), and log (UACR1) (P< 0.0001). After additional adjustment for body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, smoking history, diabetes, estimated glomerular filtration rate (eGFR), history of myocardial infarction (MI) or stroke, and medication use, log MR-proADM remained significantly associated with greater pulse pressure (P = 0.001), log LVMi (P = 0.029), and log (UACR1) (P = 0.002).ConclusionsIn African-American adults with hypertension, plasma MR-proADM is independently associated with pulse pressure, LVMi, and albuminuria and is a potential biomarker for target organ damage.

AB - BackgroundAfrican Americans with hypertension are prone to target-organ damage and adverse cardiovascular events. Biomarkers for early detection of target-organ damage in this ethnic group are needed. Adrenomedullin (ADM) is a circulating vasoactive peptide with vasodilatory and antiproliferative effects that has been reported to be elevated in adults with hypertension.MethodsWe investigated the associations of plasma levels of mid-regional pro-ADM (MR-proADM) with pulse pressure, left ventricular mass (LVM), and albuminuria in 1,034 African-American adults (65 9 years, 72% women) with hypertension. MR-proADM was measured by an immunoluminometric assay, LVM was assessed by 2-dimensional echocardiography, and albuminuria was assessed by urine albumin:creatinine ratio (UACR). Multivariable regression analyses were used to assess whether plasma MR-proADM was independently associated with pulse pressure, LVM indexed by height to the power 2.7 (LVMi), and UACR.ResultsPlasma MR-proADM was significantly correlated (P < 0.001) with pulse pressure, LVMi, and UACR. In separate multivariable linear regression models that adjusted for age and sex, log MR-proADM was associated with greater pulse pressure (P = 0.007), log LVMi (P = 0.001), and log (UACR1) (P< 0.0001). After additional adjustment for body mass index (BMI), total and high-density lipoprotein (HDL) cholesterol, smoking history, diabetes, estimated glomerular filtration rate (eGFR), history of myocardial infarction (MI) or stroke, and medication use, log MR-proADM remained significantly associated with greater pulse pressure (P = 0.001), log LVMi (P = 0.029), and log (UACR1) (P = 0.002).ConclusionsIn African-American adults with hypertension, plasma MR-proADM is independently associated with pulse pressure, LVMi, and albuminuria and is a potential biomarker for target organ damage.

UR - http://www.scopus.com/inward/record.url?scp=68149091428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68149091428&partnerID=8YFLogxK

U2 - 10.1038/ajh.2009.82

DO - 10.1038/ajh.2009.82

M3 - Article

VL - 22

SP - 860

EP - 866

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 8

ER -