TY - JOUR
T1 - Microvesicles in vascular homeostasis and diseases position paper of the european society of cardiology (ESC) working group on atherosclerosis and vascular biology
AU - Ridger, Victoria C.
AU - Boulanger, Chantal M.
AU - Angelillo-Scherrer, Anne
AU - Badimon, Lina
AU - Blanc-Brude, Olivier
AU - Bochaton-Piallat, Marie Luce
AU - Boilard, Eric
AU - Buzas, Edit I.
AU - Caporali, Andreas
AU - Dignat-George, Francoise
AU - Evans, Paul C.
AU - Lacroix, Romaric
AU - Lutgens, Esther
AU - Ketelhuth, Daniel F.J.
AU - Nieuwland, Rienk
AU - Toti, Florence
AU - Tuñon, Jose
AU - Weber, Christian
AU - Hoefer, Imo E.
AU - Lip, Gregory Y.H.
AU - Werner, Nikos
AU - Shantsila, Eduard
AU - ten Cate, Hugo
AU - Thomas, Mark
AU - Harrison, Paul
N1 - Publisher Copyright:
© Schattauer 2017.
PY - 2017
Y1 - 2017
N2 - Microvesicles are members of the family of extracellular vesicles shed from the plasma membrane of activated or apoptotic cells. Microvesicles were initially characterised by their pro-coagulant activity and described as “microparticles”. There is mounting evidence revealing a role for microvesicles in intercellular communication, with particular relevance to hemostasis and vascular biology. Coupled with this, the potential of microvesicles as meaningful biomarkers is under intense investigation. This Position Paper will summarise the current knowledge on the mechanisms of formation and composition of microvesicles of endothelial, platelet, red blood cell and leukocyte origin. This paper will also review and discuss the different methods used for their analysis and quantification, will underline the potential biological roles of these vesicles with respect to vascular homeostasis and thrombosis and define important themes for future research.
AB - Microvesicles are members of the family of extracellular vesicles shed from the plasma membrane of activated or apoptotic cells. Microvesicles were initially characterised by their pro-coagulant activity and described as “microparticles”. There is mounting evidence revealing a role for microvesicles in intercellular communication, with particular relevance to hemostasis and vascular biology. Coupled with this, the potential of microvesicles as meaningful biomarkers is under intense investigation. This Position Paper will summarise the current knowledge on the mechanisms of formation and composition of microvesicles of endothelial, platelet, red blood cell and leukocyte origin. This paper will also review and discuss the different methods used for their analysis and quantification, will underline the potential biological roles of these vesicles with respect to vascular homeostasis and thrombosis and define important themes for future research.
KW - Atherothrombosis
KW - Cell-cell interactions
KW - Inflammatory mediators
KW - Macrophage
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U2 - 10.1160/TH16-12-0943
DO - 10.1160/TH16-12-0943
M3 - Article
C2 - 28569921
AN - SCOPUS:85021631875
SN - 0340-6245
VL - 117
SP - 1296
EP - 1316
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
IS - 7
ER -