Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis

Jessica J. Field, A. Jonathan Singh, Arun Kanakkanthara, Tu'ikolongahau Halafihi, Peter T. Northcote, John H. Miller

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Zampanolide (1), a 20-membered macrolide from a Tongan marine sponge, stabilizes microtubules and blocks cells in G2/M of the cell cycle. Zampanolide is cytotoxic in the low nanomolar range and induces microtubule bundles in cells. It leads to tubulin assembly in cells and in purified tubulin preparations and is not a substrate for the P-glycoprotein drug efflux pump. Zampanolide, with only four stereogenic centers, may be amenable to large-scale synthetic preparation.

Original languageEnglish (US)
Pages (from-to)7328-7332
Number of pages5
JournalJournal of Medicinal Chemistry
Volume52
Issue number22
DOIs
StatePublished - Nov 26 2009
Externally publishedYes

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Macrolides
Porifera
Microtubules
Tubulin
P-Glycoprotein
Cell Cycle
Pharmaceutical Preparations
zampanolide

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. / Field, Jessica J.; Singh, A. Jonathan; Kanakkanthara, Arun; Halafihi, Tu'ikolongahau; Northcote, Peter T.; Miller, John H.

In: Journal of Medicinal Chemistry, Vol. 52, No. 22, 26.11.2009, p. 7328-7332.

Research output: Contribution to journalArticle

Field, Jessica J. ; Singh, A. Jonathan ; Kanakkanthara, Arun ; Halafihi, Tu'ikolongahau ; Northcote, Peter T. ; Miller, John H. / Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. In: Journal of Medicinal Chemistry. 2009 ; Vol. 52, No. 22. pp. 7328-7332.
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