Microscopic colitis: A review

Darrell S. Pardi, Thomas Christopher Smyrk, William J. Tremaine, William J. Sandborn

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Microscopic colitis is a relatively common cause of chronic watery diarrhea, often accompanied by abdominal pain and weight loss. The colonic mucosa appears normal grossly, and the diagnosis is made when there is an intraepithelial lymphocytosis and a mixed inflammatory infiltrate in the lamina propria. The two main subtypes, collagenous and lymphocytic colitis, are similar clinically and histologically, distinguished by the presence or absence of a thickened subepithelial collagen band. Many potential pathophysiological mechanisms have been described, although none have been conclusively proved. There is a paucity of randomized treatment trials in these patients, although a rational approach to therapy often leads to satisfactory control of symptoms.

Original languageEnglish (US)
Pages (from-to)794-802
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume97
Issue number4
DOIs
StatePublished - 2002

Fingerprint

Microscopic Colitis
Mucous Membrane
Lymphocytic Colitis
Collagenous Colitis
Lymphocytosis
Abdominal Pain
Weight Loss
Diarrhea
Collagen
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pardi, D. S., Smyrk, T. C., Tremaine, W. J., & Sandborn, W. J. (2002). Microscopic colitis: A review. American Journal of Gastroenterology, 97(4), 794-802. https://doi.org/10.1016/S0002-9270(02)03951-5

Microscopic colitis : A review. / Pardi, Darrell S.; Smyrk, Thomas Christopher; Tremaine, William J.; Sandborn, William J.

In: American Journal of Gastroenterology, Vol. 97, No. 4, 2002, p. 794-802.

Research output: Contribution to journalArticle

Pardi, DS, Smyrk, TC, Tremaine, WJ & Sandborn, WJ 2002, 'Microscopic colitis: A review', American Journal of Gastroenterology, vol. 97, no. 4, pp. 794-802. https://doi.org/10.1016/S0002-9270(02)03951-5
Pardi, Darrell S. ; Smyrk, Thomas Christopher ; Tremaine, William J. ; Sandborn, William J. / Microscopic colitis : A review. In: American Journal of Gastroenterology. 2002 ; Vol. 97, No. 4. pp. 794-802.
@article{4b594601533e47419904d7d2a00d2d37,
title = "Microscopic colitis: A review",
abstract = "Microscopic colitis is a relatively common cause of chronic watery diarrhea, often accompanied by abdominal pain and weight loss. The colonic mucosa appears normal grossly, and the diagnosis is made when there is an intraepithelial lymphocytosis and a mixed inflammatory infiltrate in the lamina propria. The two main subtypes, collagenous and lymphocytic colitis, are similar clinically and histologically, distinguished by the presence or absence of a thickened subepithelial collagen band. Many potential pathophysiological mechanisms have been described, although none have been conclusively proved. There is a paucity of randomized treatment trials in these patients, although a rational approach to therapy often leads to satisfactory control of symptoms.",
author = "Pardi, {Darrell S.} and Smyrk, {Thomas Christopher} and Tremaine, {William J.} and Sandborn, {William J.}",
year = "2002",
doi = "10.1016/S0002-9270(02)03951-5",
language = "English (US)",
volume = "97",
pages = "794--802",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Microscopic colitis

T2 - A review

AU - Pardi, Darrell S.

AU - Smyrk, Thomas Christopher

AU - Tremaine, William J.

AU - Sandborn, William J.

PY - 2002

Y1 - 2002

N2 - Microscopic colitis is a relatively common cause of chronic watery diarrhea, often accompanied by abdominal pain and weight loss. The colonic mucosa appears normal grossly, and the diagnosis is made when there is an intraepithelial lymphocytosis and a mixed inflammatory infiltrate in the lamina propria. The two main subtypes, collagenous and lymphocytic colitis, are similar clinically and histologically, distinguished by the presence or absence of a thickened subepithelial collagen band. Many potential pathophysiological mechanisms have been described, although none have been conclusively proved. There is a paucity of randomized treatment trials in these patients, although a rational approach to therapy often leads to satisfactory control of symptoms.

AB - Microscopic colitis is a relatively common cause of chronic watery diarrhea, often accompanied by abdominal pain and weight loss. The colonic mucosa appears normal grossly, and the diagnosis is made when there is an intraepithelial lymphocytosis and a mixed inflammatory infiltrate in the lamina propria. The two main subtypes, collagenous and lymphocytic colitis, are similar clinically and histologically, distinguished by the presence or absence of a thickened subepithelial collagen band. Many potential pathophysiological mechanisms have been described, although none have been conclusively proved. There is a paucity of randomized treatment trials in these patients, although a rational approach to therapy often leads to satisfactory control of symptoms.

UR - http://www.scopus.com/inward/record.url?scp=0036121955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036121955&partnerID=8YFLogxK

U2 - 10.1016/S0002-9270(02)03951-5

DO - 10.1016/S0002-9270(02)03951-5

M3 - Article

C2 - 12003412

AN - SCOPUS:0036121955

VL - 97

SP - 794

EP - 802

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 4

ER -