Microscopic Colitis

Darrell S. Pardi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Microscopic colitis is a common cause of chronic watery diarrhea, especially in the elderly. The incidence of this condition is increasing, perhaps due to an association with several commonly used medications. The two subtypes, lymphocytic and collagenous colitis, are only distinguishable histologically. The diagnosis relies on colon biopsies, which show an intra-epithelial lymphocytosis and mixed lamina propria inflammation. In collagenous colitis, the subepithelial collagen band is thickened. The main differential diagnosis is irritable bowel syndrome, and histology is required to distinguish these entities. Several treatment options have been reported, but bismuth subsalicylate and budesonide seem to be the most effective. Many patients require maintenance therapy, but the prognosis is good, with most patients responding to treatment, and no known increased risk of colon cancer or death.

Original languageEnglish (US)
Title of host publicationPractical Gastroenterology and Hepatology
Subtitle of host publicationSmall and Large Intestine and Pancreas
PublisherWiley-Blackwell
Pages321-325
Number of pages5
ISBN (Print)9781405182744
DOIs
StatePublished - Aug 31 2010

Keywords

  • Collagenous colitis
  • Lymphocytic colitis
  • Microscopic colitis

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Pardi, D. S. (2010). Microscopic Colitis. In Practical Gastroenterology and Hepatology: Small and Large Intestine and Pancreas (pp. 321-325). Wiley-Blackwell. https://doi.org/10.1002/9781444328417.ch45