Microscopic colitis

Darrell S. Pardi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Microscopic colitis has 2 main subtypes, collagenous colitis and lymphocytic colitis, that are similar clinically and histologically and are distinguished mainly by the presence or absence of a thickened subepithelial collagen band. Microscopic colitis accounts for approximately 10% of chronic watery diarrhea and may be associated with abdominal pain and mild weight loss. It is typically diagnosed in the sixth to eighth decade of life, and there is a female predominance that is more striking for collagenous colitis than for lymphocytic colitis. Endoscopic and radiographic findings of the colon appear normal. Diagnosis is made by colonic biopsy, which shows an intraepithelial lymphocytosis and a mixed inflammatory infiltrate in the lamina propria. Many potential treatments have been reported, but few have been subjected to controlled treatment trials. A stepwise approach to therapy often leads to satisfactory control of symptoms.

Original languageEnglish (US)
Pages (from-to)614-616
Number of pages3
JournalMayo Clinic Proceedings
Volume78
Issue number5
StatePublished - May 1 2003

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Microscopic Colitis
Lymphocytic Colitis
Collagenous Colitis
Lymphocytosis
Abdominal Pain
Weight Loss
Diarrhea
Colon
Mucous Membrane
Collagen
Therapeutics
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pardi, D. S. (2003). Microscopic colitis. Mayo Clinic Proceedings, 78(5), 614-616.

Microscopic colitis. / Pardi, Darrell S.

In: Mayo Clinic Proceedings, Vol. 78, No. 5, 01.05.2003, p. 614-616.

Research output: Contribution to journalArticle

Pardi, DS 2003, 'Microscopic colitis', Mayo Clinic Proceedings, vol. 78, no. 5, pp. 614-616.
Pardi DS. Microscopic colitis. Mayo Clinic Proceedings. 2003 May 1;78(5):614-616.
Pardi, Darrell S. / Microscopic colitis. In: Mayo Clinic Proceedings. 2003 ; Vol. 78, No. 5. pp. 614-616.
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