Microsatellite mapping of the gene causing weaver disease in cattle will allow the study of an associated quantitative trait locus

Michel Georges, Allan B Dietz, Anuradha Mishra, Dahlia Nielsen, Leslie S. Sargeant, Anita Sorensen, Michael R. Steele, Xuyun Zhao, Horst Leipold, James E. Womack, Mark Lathrop

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

A genetic disease in cattle, progressive degenerative myeloencephalopathy (weaver disease), is associated with increased milk production. This association could result from population stratification, from a pleiotropic effect of a single gene, or from linkage disequilibrium between the gene causing weaver disease and a quantitative trait locus (QTL) for milk production. To test these hypotheses, we performed an extensive linkage study in a bovine pedigree segregating for the weaver condition and identified a microsatellite locus (TGLA116) closely linked to the weaver gene (zmax, 8.15; θ, 0.03). TGLA116 and, by extension, the weaver locus were assigned to bovine synteny group 13. This microsatellite can be used to identify weaver carriers, to select against this genetic defect, and to study the effect of the corresponding chromosomal region on milk production in Brown Swiss and other breeds of cattle.

Original languageEnglish (US)
Pages (from-to)1058-1062
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number3
StatePublished - Feb 1 1993
Externally publishedYes

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Cattle Diseases
Chromosome Mapping
Quantitative Trait Loci
Microsatellite Repeats
Milk
Genes
Synteny
Inborn Genetic Diseases
Linkage Disequilibrium
Pedigree
Population

Keywords

  • Ataria
  • Linkage
  • QTL

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Microsatellite mapping of the gene causing weaver disease in cattle will allow the study of an associated quantitative trait locus. / Georges, Michel; Dietz, Allan B; Mishra, Anuradha; Nielsen, Dahlia; Sargeant, Leslie S.; Sorensen, Anita; Steele, Michael R.; Zhao, Xuyun; Leipold, Horst; Womack, James E.; Lathrop, Mark.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 3, 01.02.1993, p. 1058-1062.

Research output: Contribution to journalArticle

Georges, M, Dietz, AB, Mishra, A, Nielsen, D, Sargeant, LS, Sorensen, A, Steele, MR, Zhao, X, Leipold, H, Womack, JE & Lathrop, M 1993, 'Microsatellite mapping of the gene causing weaver disease in cattle will allow the study of an associated quantitative trait locus', Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 3, pp. 1058-1062.
Georges, Michel ; Dietz, Allan B ; Mishra, Anuradha ; Nielsen, Dahlia ; Sargeant, Leslie S. ; Sorensen, Anita ; Steele, Michael R. ; Zhao, Xuyun ; Leipold, Horst ; Womack, James E. ; Lathrop, Mark. / Microsatellite mapping of the gene causing weaver disease in cattle will allow the study of an associated quantitative trait locus. In: Proceedings of the National Academy of Sciences of the United States of America. 1993 ; Vol. 90, No. 3. pp. 1058-1062.
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AU - Sorensen, Anita

AU - Steele, Michael R.

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