TY - JOUR
T1 - MicroRNAs in ER Stress
T2 - Divergent Roles in Cell Fate Decisions
AU - Malhi, Harmeet
N1 - Funding Information:
Acknowledgments This work was supported by NIH Grant DK97178 (to HM). The author is grateful to Ms. Courtney Hoover for her excellent secretarial support.
Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - MicroRNAs are small, noncoding RNAs which regulate protein expression post-transcriptionally. They respond to changes in a cell's environment and can promote cell death or cell survival depending on the context. Recent studies have linked microRNAs to the unfolded protein response pathway. This pathway is activated in the endoplasmic reticulum by conditions which interfere with the normal functions of the endoplasmic reticulum. The cell fate outcomes consequent to the activation of the unfolded protein response are binary, either cell survival or cell death. MicroRNAs can regulate multiple components of this pathway to tip the cell towards either fate. Inositol-requiring enzyme 1 alpha, a canonical unfolded protein response sensor and mediator, has inherent endoribonuclease activity. Interestingly, recently, it has been demonstrated that it can target microRNAs in addition to its previously known targets. This review highlights key papers in this rapidly emerging field.
AB - MicroRNAs are small, noncoding RNAs which regulate protein expression post-transcriptionally. They respond to changes in a cell's environment and can promote cell death or cell survival depending on the context. Recent studies have linked microRNAs to the unfolded protein response pathway. This pathway is activated in the endoplasmic reticulum by conditions which interfere with the normal functions of the endoplasmic reticulum. The cell fate outcomes consequent to the activation of the unfolded protein response are binary, either cell survival or cell death. MicroRNAs can regulate multiple components of this pathway to tip the cell towards either fate. Inositol-requiring enzyme 1 alpha, a canonical unfolded protein response sensor and mediator, has inherent endoribonuclease activity. Interestingly, recently, it has been demonstrated that it can target microRNAs in addition to its previously known targets. This review highlights key papers in this rapidly emerging field.
KW - Activating transcription factor 4
KW - Activating transcription factor 6 alpha
KW - Apoptosis
KW - C/EBP homologous protein
KW - Inositol-requiring enzyme 1 alpha
KW - Protein kinase-like ER kinase
KW - Unfolded protein response
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U2 - 10.1007/s40139-014-0046-y
DO - 10.1007/s40139-014-0046-y
M3 - Review article
AN - SCOPUS:84962419602
VL - 2
SP - 117
EP - 122
JO - Current Pathobiology Reports
JF - Current Pathobiology Reports
SN - 2167-485X
IS - 3
ER -