Abstract
MicroRNAs are small, noncoding RNAs which regulate protein expression post-transcriptionally. They respond to changes in a cell's environment and can promote cell death or cell survival depending on the context. Recent studies have linked microRNAs to the unfolded protein response pathway. This pathway is activated in the endoplasmic reticulum by conditions which interfere with the normal functions of the endoplasmic reticulum. The cell fate outcomes consequent to the activation of the unfolded protein response are binary, either cell survival or cell death. MicroRNAs can regulate multiple components of this pathway to tip the cell towards either fate. Inositol-requiring enzyme 1 alpha, a canonical unfolded protein response sensor and mediator, has inherent endoribonuclease activity. Interestingly, recently, it has been demonstrated that it can target microRNAs in addition to its previously known targets. This review highlights key papers in this rapidly emerging field.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-122 |
| Number of pages | 6 |
| Journal | Current Pathobiology Reports |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2014 |
| Externally published | Yes |
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Keywords
- Activating transcription factor 4
- Activating transcription factor 6 alpha
- Apoptosis
- C/EBP homologous protein
- Inositol-requiring enzyme 1 alpha
- Protein kinase-like ER kinase
- Unfolded protein response
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Pathology and Forensic Medicine
- Cancer Research
Cite this
MicroRNAs in ER Stress : Divergent Roles in Cell Fate Decisions. / Malhi, Harmeet M.
In: Current Pathobiology Reports, Vol. 2, No. 3, 01.09.2014, p. 117-122.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - MicroRNAs in ER Stress
T2 - Divergent Roles in Cell Fate Decisions
AU - Malhi, Harmeet M
PY - 2014/9/1
Y1 - 2014/9/1
N2 - MicroRNAs are small, noncoding RNAs which regulate protein expression post-transcriptionally. They respond to changes in a cell's environment and can promote cell death or cell survival depending on the context. Recent studies have linked microRNAs to the unfolded protein response pathway. This pathway is activated in the endoplasmic reticulum by conditions which interfere with the normal functions of the endoplasmic reticulum. The cell fate outcomes consequent to the activation of the unfolded protein response are binary, either cell survival or cell death. MicroRNAs can regulate multiple components of this pathway to tip the cell towards either fate. Inositol-requiring enzyme 1 alpha, a canonical unfolded protein response sensor and mediator, has inherent endoribonuclease activity. Interestingly, recently, it has been demonstrated that it can target microRNAs in addition to its previously known targets. This review highlights key papers in this rapidly emerging field.
AB - MicroRNAs are small, noncoding RNAs which regulate protein expression post-transcriptionally. They respond to changes in a cell's environment and can promote cell death or cell survival depending on the context. Recent studies have linked microRNAs to the unfolded protein response pathway. This pathway is activated in the endoplasmic reticulum by conditions which interfere with the normal functions of the endoplasmic reticulum. The cell fate outcomes consequent to the activation of the unfolded protein response are binary, either cell survival or cell death. MicroRNAs can regulate multiple components of this pathway to tip the cell towards either fate. Inositol-requiring enzyme 1 alpha, a canonical unfolded protein response sensor and mediator, has inherent endoribonuclease activity. Interestingly, recently, it has been demonstrated that it can target microRNAs in addition to its previously known targets. This review highlights key papers in this rapidly emerging field.
KW - Activating transcription factor 4
KW - Activating transcription factor 6 alpha
KW - Apoptosis
KW - C/EBP homologous protein
KW - Inositol-requiring enzyme 1 alpha
KW - Protein kinase-like ER kinase
KW - Unfolded protein response
UR - http://www.scopus.com/inward/record.url?scp=84962419602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962419602&partnerID=8YFLogxK
U2 - 10.1007/s40139-014-0046-y
DO - 10.1007/s40139-014-0046-y
M3 - Review article
AN - SCOPUS:84962419602
VL - 2
SP - 117
EP - 122
JO - Current Pathobiology Reports
JF - Current Pathobiology Reports
SN - 2167-485X
IS - 3
ER -