MicroRNAs in Cholangiopathies

Steven P. O’Hara; Sergio A. Gradilone; Tetyana V. Masyuk; James H. Tabibian; Nicholas F. LaRusso

doi:10.1007/s40139-014-0048-9

MicroRNAs in Cholangiopathies

Steven P. O’Hara, Sergio A. Gradilone, Tetyana V. Masyuk, James H. Tabibian, Nicholas F. LaRusso

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Cholangiocytes, the cells lining bile ducts, comprise a small fraction of the total cellular component of the liver, yet perform the essential role of bile modification and transport of biliary and blood constituents. Cholangiopathies are a diverse group of biliary disorders with the cholangiocyte as the target cell; the etiopathogenesis of most cholangiopathies remains obscure. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. These small RNAs may not only be involved in the etiopathogenesis of disease, but are also showing promise as diagnostic and prognostic tools. In this brief review, we summarize recent work regarding the role of microRNAs in the etiopathogenesis of several cholangiopathies, and discuss their utility as prognostic and diagnostic tools.

Original language	English (US)
Pages (from-to)	133-142
Number of pages	10
Journal	Current Pathobiology Reports
Volume	2
Issue number	3
DOIs	https://doi.org/10.1007/s40139-014-0048-9
State	Published - Sep 1 2014

Keywords

Biliary atresia
Cholangiocarcinoma
Cholangiocytes
MicroRNAs, cholangiopathies
Polycystic liver disease
Primary biliary cirrhosis
Primary sclerosing cholangitis

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Cell Biology
Cancer Research

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10.1007/s40139-014-0048-9

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title = "MicroRNAs in Cholangiopathies",

abstract = "Cholangiocytes, the cells lining bile ducts, comprise a small fraction of the total cellular component of the liver, yet perform the essential role of bile modification and transport of biliary and blood constituents. Cholangiopathies are a diverse group of biliary disorders with the cholangiocyte as the target cell; the etiopathogenesis of most cholangiopathies remains obscure. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. These small RNAs may not only be involved in the etiopathogenesis of disease, but are also showing promise as diagnostic and prognostic tools. In this brief review, we summarize recent work regarding the role of microRNAs in the etiopathogenesis of several cholangiopathies, and discuss their utility as prognostic and diagnostic tools.",

keywords = "Biliary atresia, Cholangiocarcinoma, Cholangiocytes, MicroRNAs, cholangiopathies, Polycystic liver disease, Primary biliary cirrhosis, Primary sclerosing cholangitis",

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AU - O’Hara, Steven P.

AU - Gradilone, Sergio A.

AU - Masyuk, Tetyana V.

AU - Tabibian, James H.

AU - LaRusso, Nicholas F.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Cholangiocytes, the cells lining bile ducts, comprise a small fraction of the total cellular component of the liver, yet perform the essential role of bile modification and transport of biliary and blood constituents. Cholangiopathies are a diverse group of biliary disorders with the cholangiocyte as the target cell; the etiopathogenesis of most cholangiopathies remains obscure. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. These small RNAs may not only be involved in the etiopathogenesis of disease, but are also showing promise as diagnostic and prognostic tools. In this brief review, we summarize recent work regarding the role of microRNAs in the etiopathogenesis of several cholangiopathies, and discuss their utility as prognostic and diagnostic tools.

AB - Cholangiocytes, the cells lining bile ducts, comprise a small fraction of the total cellular component of the liver, yet perform the essential role of bile modification and transport of biliary and blood constituents. Cholangiopathies are a diverse group of biliary disorders with the cholangiocyte as the target cell; the etiopathogenesis of most cholangiopathies remains obscure. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. These small RNAs may not only be involved in the etiopathogenesis of disease, but are also showing promise as diagnostic and prognostic tools. In this brief review, we summarize recent work regarding the role of microRNAs in the etiopathogenesis of several cholangiopathies, and discuss their utility as prognostic and diagnostic tools.

KW - Biliary atresia

KW - Cholangiocarcinoma

KW - Cholangiocytes

KW - MicroRNAs, cholangiopathies

KW - Polycystic liver disease

KW - Primary biliary cirrhosis

KW - Primary sclerosing cholangitis

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U2 - 10.1007/s40139-014-0048-9

DO - 10.1007/s40139-014-0048-9

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JO - Current Pathobiology Reports

JF - Current Pathobiology Reports

IS - 3

ER -

MicroRNAs in Cholangiopathies

Abstract

Keywords

ASJC Scopus subject areas

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