MicroRNAs in Cholangiopathies

Steven P. O’Hara, Sergio A. Gradilone, Tetyana V. Masyuk, James H. Tabibian, Nicholas F. LaRusso

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Cholangiocytes, the cells lining bile ducts, comprise a small fraction of the total cellular component of the liver, yet perform the essential role of bile modification and transport of biliary and blood constituents. Cholangiopathies are a diverse group of biliary disorders with the cholangiocyte as the target cell; the etiopathogenesis of most cholangiopathies remains obscure. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. These small RNAs may not only be involved in the etiopathogenesis of disease, but are also showing promise as diagnostic and prognostic tools. In this brief review, we summarize recent work regarding the role of microRNAs in the etiopathogenesis of several cholangiopathies, and discuss their utility as prognostic and diagnostic tools.

Original languageEnglish (US)
Pages (from-to)133-142
Number of pages10
JournalCurrent Pathobiology Reports
Volume2
Issue number3
DOIs
StatePublished - Sep 1 2014

Keywords

  • Biliary atresia
  • Cholangiocarcinoma
  • Cholangiocytes
  • MicroRNAs, cholangiopathies
  • Polycystic liver disease
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology
  • Cancer Research

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