MicroRNAs in cholangiociliopathies

Tatyana Masyuk, Anatoliy Masyuk, Nicholas LaRusso

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

This review is focused on current findings implicating miRNAs in the polycystic liver diseases, which we categorized as cholangiociliopathies. Our recent data suggest that deregulation of miRNA pathways is emerging as a novel mechanism in the development of cholangiociliopathies. Experimental evidence demonstrates that miRNAs (i.e., miR-15a) influence hepatic cyst growth by affecting the expression of the cell cycle regulator, Cdc25A. Given that abnormalities in many cellular processes (i.e., cell cycle regulation, cell proliferation, cAMP and calcium signaling, the EGF-stimulated mitogen-activated protein kinase (MAPK) pathway and fluid secretion) contribute to the hepatic cystogenesis, the potential role of miRNAs in regulation of these processes is discussed.

Original languageEnglish (US)
Pages (from-to)1324-1328
Number of pages5
JournalCell Cycle
Volume8
Issue number9
DOIs
StatePublished - May 1 2009

Keywords

  • Cdc25A
  • Cholangiociliopathies
  • Cholangiocyte
  • Proliferation
  • miR-15a
  • miRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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