MicroRNAs and benign biliary tract diseases

Sergio A. Gradilone, Steven P. O'Hara, Tetyana V. Masyuk, Maria Jose Lorenzo Pisarello, Nicholas F La Russo

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cholangiocytes, the epithelial cells lining the biliary tree, represent only a small portion of the total liver cell population (3-5%), but they are responsible for the secretion of up to 40% of total daily bile volume. In addition, cholangiocytes are the target of a diverse group of liver diseases affecting the biliary tract, the cholangiopathies; for most of these conditions, the pathological mechanisms are unclear. MicroRNAs (miRNAs) are small, noncoding RNAs that posttranscriptionally regulate gene expression. Thus, it is not surprising that altered miRNA profiles underlie the dysregulation of several proteins involved in the pathobiology of the cholangiopathies, as well as showing promise as diagnostic and prognostic tools. Here the authors review recent work relevant to the role of miRNAs in the etiopathogenesis of several of the cholangiopathies (i.e., fibroinflammatory cholangiopathies and polycystic liver diseases), discuss their value as prognostic and diagnostic tools, and provide suggestions for further research.

Original languageEnglish (US)
Pages (from-to)26-35
Number of pages10
JournalSeminars in Liver Disease
Volume35
Issue number1
DOIs
StatePublished - Feb 1 2015

Fingerprint

Biliary Tract Diseases
MicroRNAs
Biliary Tract
Small Untranslated RNA
Bile
Liver Diseases
Epithelial Cells
Gene Expression
Liver
Research
Population
Proteins

Keywords

  • biliary atresia
  • cholangiocarcinoma
  • cholangiocytes
  • cholangiopathies
  • microRNAs
  • polycystic liver disease
  • primary biliary cirrhosis
  • primary sclerosing cholangitis

ASJC Scopus subject areas

  • Hepatology

Cite this

Gradilone, S. A., O'Hara, S. P., Masyuk, T. V., Pisarello, M. J. L., & La Russo, N. F. (2015). MicroRNAs and benign biliary tract diseases. Seminars in Liver Disease, 35(1), 26-35. https://doi.org/10.1055/s-0034-1397346

MicroRNAs and benign biliary tract diseases. / Gradilone, Sergio A.; O'Hara, Steven P.; Masyuk, Tetyana V.; Pisarello, Maria Jose Lorenzo; La Russo, Nicholas F.

In: Seminars in Liver Disease, Vol. 35, No. 1, 01.02.2015, p. 26-35.

Research output: Contribution to journalArticle

Gradilone, SA, O'Hara, SP, Masyuk, TV, Pisarello, MJL & La Russo, NF 2015, 'MicroRNAs and benign biliary tract diseases', Seminars in Liver Disease, vol. 35, no. 1, pp. 26-35. https://doi.org/10.1055/s-0034-1397346
Gradilone, Sergio A. ; O'Hara, Steven P. ; Masyuk, Tetyana V. ; Pisarello, Maria Jose Lorenzo ; La Russo, Nicholas F. / MicroRNAs and benign biliary tract diseases. In: Seminars in Liver Disease. 2015 ; Vol. 35, No. 1. pp. 26-35.
@article{4cda070f02b44f9f8593483847d979ee,
title = "MicroRNAs and benign biliary tract diseases",
abstract = "Cholangiocytes, the epithelial cells lining the biliary tree, represent only a small portion of the total liver cell population (3-5{\%}), but they are responsible for the secretion of up to 40{\%} of total daily bile volume. In addition, cholangiocytes are the target of a diverse group of liver diseases affecting the biliary tract, the cholangiopathies; for most of these conditions, the pathological mechanisms are unclear. MicroRNAs (miRNAs) are small, noncoding RNAs that posttranscriptionally regulate gene expression. Thus, it is not surprising that altered miRNA profiles underlie the dysregulation of several proteins involved in the pathobiology of the cholangiopathies, as well as showing promise as diagnostic and prognostic tools. Here the authors review recent work relevant to the role of miRNAs in the etiopathogenesis of several of the cholangiopathies (i.e., fibroinflammatory cholangiopathies and polycystic liver diseases), discuss their value as prognostic and diagnostic tools, and provide suggestions for further research.",
keywords = "biliary atresia, cholangiocarcinoma, cholangiocytes, cholangiopathies, microRNAs, polycystic liver disease, primary biliary cirrhosis, primary sclerosing cholangitis",
author = "Gradilone, {Sergio A.} and O'Hara, {Steven P.} and Masyuk, {Tetyana V.} and Pisarello, {Maria Jose Lorenzo} and {La Russo}, {Nicholas F}",
year = "2015",
month = "2",
day = "1",
doi = "10.1055/s-0034-1397346",
language = "English (US)",
volume = "35",
pages = "26--35",
journal = "Seminars in Liver Disease",
issn = "0272-8087",
publisher = "Thieme Medical Publishers",
number = "1",

}

TY - JOUR

T1 - MicroRNAs and benign biliary tract diseases

AU - Gradilone, Sergio A.

AU - O'Hara, Steven P.

AU - Masyuk, Tetyana V.

AU - Pisarello, Maria Jose Lorenzo

AU - La Russo, Nicholas F

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Cholangiocytes, the epithelial cells lining the biliary tree, represent only a small portion of the total liver cell population (3-5%), but they are responsible for the secretion of up to 40% of total daily bile volume. In addition, cholangiocytes are the target of a diverse group of liver diseases affecting the biliary tract, the cholangiopathies; for most of these conditions, the pathological mechanisms are unclear. MicroRNAs (miRNAs) are small, noncoding RNAs that posttranscriptionally regulate gene expression. Thus, it is not surprising that altered miRNA profiles underlie the dysregulation of several proteins involved in the pathobiology of the cholangiopathies, as well as showing promise as diagnostic and prognostic tools. Here the authors review recent work relevant to the role of miRNAs in the etiopathogenesis of several of the cholangiopathies (i.e., fibroinflammatory cholangiopathies and polycystic liver diseases), discuss their value as prognostic and diagnostic tools, and provide suggestions for further research.

AB - Cholangiocytes, the epithelial cells lining the biliary tree, represent only a small portion of the total liver cell population (3-5%), but they are responsible for the secretion of up to 40% of total daily bile volume. In addition, cholangiocytes are the target of a diverse group of liver diseases affecting the biliary tract, the cholangiopathies; for most of these conditions, the pathological mechanisms are unclear. MicroRNAs (miRNAs) are small, noncoding RNAs that posttranscriptionally regulate gene expression. Thus, it is not surprising that altered miRNA profiles underlie the dysregulation of several proteins involved in the pathobiology of the cholangiopathies, as well as showing promise as diagnostic and prognostic tools. Here the authors review recent work relevant to the role of miRNAs in the etiopathogenesis of several of the cholangiopathies (i.e., fibroinflammatory cholangiopathies and polycystic liver diseases), discuss their value as prognostic and diagnostic tools, and provide suggestions for further research.

KW - biliary atresia

KW - cholangiocarcinoma

KW - cholangiocytes

KW - cholangiopathies

KW - microRNAs

KW - polycystic liver disease

KW - primary biliary cirrhosis

KW - primary sclerosing cholangitis

UR - http://www.scopus.com/inward/record.url?scp=84928532843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928532843&partnerID=8YFLogxK

U2 - 10.1055/s-0034-1397346

DO - 10.1055/s-0034-1397346

M3 - Article

C2 - 25632932

AN - SCOPUS:84928532843

VL - 35

SP - 26

EP - 35

JO - Seminars in Liver Disease

JF - Seminars in Liver Disease

SN - 0272-8087

IS - 1

ER -