TY - JOUR
T1 - MicroRNA delivery systems in glioma therapy and perspectives
T2 - A systematic review
AU - Jiménez-Morales, José Marcos
AU - Hernández-Cuenca, Yanet Elisa
AU - Reyes-Abrahantes, Ander
AU - Ruiz-García, Henry
AU - Barajas-Olmos, Francisco
AU - García-Ortiz, Humberto
AU - Orozco, Lorena
AU - Quiñones-Hinojosa, Alfredo
AU - Reyes-González, Jesús
AU - Abrahantes-Pérez, María del Carmen
N1 - Publisher Copyright:
© 2022
PY - 2022/9
Y1 - 2022/9
N2 - Gliomas are the deadliest of all primary brain tumors, and they constitute a serious global health problem. MicroRNAs (miRNAs) are gene expression regulators associated with glioma pathogenesis. Thus, miRNAs represent potential therapeutic agents for treating gliomas. However, miRNAs have not been established as part of the regular clinical armamentarium. This systemic review evaluates current molecular and pre-clinical studies with the aim of defining the most appealing supramolecular platform for administering therapeutic miRNA to patients with gliomas. An integrated analysis suggested that cationic lipid nanoparticles, functionalized with octa-arginine peptides, represent a potentially specific, practical, non-invasive intervention for treating gliomas. This supramolecular platform allows loading both hydrophilic (miRNA) and hydrophobic (anti-tumor drugs, like temozolomide) molecules. This systemic review is the first to describe miRNA delivery systems targeted to gliomas that integrate several types of molecules as active ingredients. Further experimental validation is warranted to confirm the practical value of miRNA delivery systems.
AB - Gliomas are the deadliest of all primary brain tumors, and they constitute a serious global health problem. MicroRNAs (miRNAs) are gene expression regulators associated with glioma pathogenesis. Thus, miRNAs represent potential therapeutic agents for treating gliomas. However, miRNAs have not been established as part of the regular clinical armamentarium. This systemic review evaluates current molecular and pre-clinical studies with the aim of defining the most appealing supramolecular platform for administering therapeutic miRNA to patients with gliomas. An integrated analysis suggested that cationic lipid nanoparticles, functionalized with octa-arginine peptides, represent a potentially specific, practical, non-invasive intervention for treating gliomas. This supramolecular platform allows loading both hydrophilic (miRNA) and hydrophobic (anti-tumor drugs, like temozolomide) molecules. This systemic review is the first to describe miRNA delivery systems targeted to gliomas that integrate several types of molecules as active ingredients. Further experimental validation is warranted to confirm the practical value of miRNA delivery systems.
KW - Drug delivery system
KW - Glioma
KW - MicroRNAs
KW - Molecular targeted therapy
KW - Translational medicine
UR - http://www.scopus.com/inward/record.url?scp=85135184184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85135184184&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2022.07.027
DO - 10.1016/j.jconrel.2022.07.027
M3 - Review article
C2 - 35905783
AN - SCOPUS:85135184184
SN - 0168-3659
VL - 349
SP - 712
EP - 730
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -