Microphotocoagulation

Selective effects of repetitive short laser pulses

Johann Roider, Franz Hillenkamp, Thomas J Flotte, Reginald Birngruber

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

Repetitive exposure to short laser pulses is shown to cause selective damage to absorbing structures (cells, organelles, or enzymes) with pulse energies below the threshold energy for single-pulse damage. Directly adjacent structures are spared in vivo. Additivity of (presumably nonphotochemical) subthreshold effects is demonstrated. Selective damage to the retinal pigment epithelium with sparing of the neural retina is shown (514 nm, 5 μs, 1-500 pulses at 500 Hz, 2- to 10-μJ pulse energy). A melanin granule model has been developed and applied to the experimental situation. Histological results as well as the basic mechanism for these effects are discussed.

Original languageEnglish (US)
Pages (from-to)8643-8647
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number18
StatePublished - Sep 15 1993
Externally publishedYes

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Retinal Pigment Epithelium
Melanins
Organelles
Retina
Lasers
Enzymes

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Microphotocoagulation : Selective effects of repetitive short laser pulses. / Roider, Johann; Hillenkamp, Franz; Flotte, Thomas J; Birngruber, Reginald.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 18, 15.09.1993, p. 8643-8647.

Research output: Contribution to journalArticle

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