TY - JOUR
T1 - Microphotocoagulation
T2 - Selective effects of repetitive short laser pulses
AU - Roider, Johann
AU - Hillenkamp, Franz
AU - Flotte, Thomas
AU - Birngruber, Reginald
PY - 1993/9/15
Y1 - 1993/9/15
N2 - Repetitive exposure to short laser pulses is shown to cause selective damage to absorbing structures (cells, organelles, or enzymes) with pulse energies below the threshold energy for single-pulse damage. Directly adjacent structures are spared in vivo. Additivity of (presumably nonphotochemical) subthreshold effects is demonstrated. Selective damage to the retinal pigment epithelium with sparing of the neural retina is shown (514 nm, 5 μs, 1-500 pulses at 500 Hz, 2- to 10-μJ pulse energy). A melanin granule model has been developed and applied to the experimental situation. Histological results as well as the basic mechanism for these effects are discussed.
AB - Repetitive exposure to short laser pulses is shown to cause selective damage to absorbing structures (cells, organelles, or enzymes) with pulse energies below the threshold energy for single-pulse damage. Directly adjacent structures are spared in vivo. Additivity of (presumably nonphotochemical) subthreshold effects is demonstrated. Selective damage to the retinal pigment epithelium with sparing of the neural retina is shown (514 nm, 5 μs, 1-500 pulses at 500 Hz, 2- to 10-μJ pulse energy). A melanin granule model has been developed and applied to the experimental situation. Histological results as well as the basic mechanism for these effects are discussed.
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M3 - Article
C2 - 8378341
AN - SCOPUS:0027284421
SN - 0027-8424
VL - 90
SP - 8643
EP - 8647
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 18
ER -