Microglia Receptors in Animal Models of Traumatic Brain Injury

Daniel Younger, Madhuvika Murugan, Kakulavarapu V. Rama Rao, LongJun Wu, Namas Chandra

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Microglia have been implicated as a key mediator of chronic inflammation following traumatic brain injury (TBI). The animal models of TBI vary significantly based on the type of brain injury (focal versus diffuse). This has made it extremely difficult to assess the role of microglia and the window of microglia activation. Hence, the focus of this review is to summarize the time course of microglia activation in various animal models of TBI. The review explores the repertoire of secondary injury mechanisms such as aberrant neurotransmitter release, oxidative stress, blood-brain barrier disruption, and production of pro-inflammatory cytokines that follow microglia activation. Since receptors act as sensors for activation, we highlight certain microglia receptors that have been implicated in TBI pathology, including fractalkine receptor (CX3CR1), purinergic receptor (P2Y12R), Toll-like receptor (TLR4), scavenger receptors, tumor necrosis factor receptor (TNF-1R), interleukin receptor (IL-1R), complement receptors, and peroxisome proliferator-activated receptor (PPAR). In addition to describing their downstream signaling pathways in TBI, we describe the functional consequences of their activation and the implication in behavioral outcomes. Taken together, this review will provide a holistic view of the role of microglia and its receptors in TBI based on animal studies.

Original languageEnglish (US)
JournalMolecular Neurobiology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Microglia
Animal Models
Interleukin Receptors
Purinergic Receptors
Complement Receptors
Scavenger Receptors
Inflammation Mediators
Peroxisome Proliferator-Activated Receptors
Toll-Like Receptor 4
Tumor Necrosis Factor Receptors
Toll-Like Receptors
Traumatic Brain Injury
Blood-Brain Barrier
Brain Injuries
Neurotransmitter Agents
Oxidative Stress
Pathology
Cytokines
Wounds and Injuries

Keywords

  • Brain injury
  • Microglia
  • Receptors

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Microglia Receptors in Animal Models of Traumatic Brain Injury. / Younger, Daniel; Murugan, Madhuvika; Rama Rao, Kakulavarapu V.; Wu, LongJun; Chandra, Namas.

In: Molecular Neurobiology, 01.01.2018.

Research output: Contribution to journalArticle

Younger, Daniel ; Murugan, Madhuvika ; Rama Rao, Kakulavarapu V. ; Wu, LongJun ; Chandra, Namas. / Microglia Receptors in Animal Models of Traumatic Brain Injury. In: Molecular Neurobiology. 2018.
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