Microglia in cerebellar plaques in Alzheimer's disease

L. A. Mattiace, P. Davies, S. H. Yen, Dennis W Dickson

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Cerebellar amyloid deposits in Alzheimer's disease were studied by immunocytochemistry and with a series of antibodies that recognize human microglia, including anti-HLA-DR, LN-1, Leu-M5 and leukocyte common antigen. Microglia formed a dense reticular array throughout the cerebellum in areas with and without amyloid deposits. In areas with compact and reticular amyloid deposits, microglia had morphological features consistent with activation, such as cytoplasmic swelling and shortening and thickening of cell processes. In areas with diffuse amyloid deposits, microglia had delicate and highly ramified processes. Nevertheless, microglial cells or their processes were detected in association with amyloid deposits of all morphological types. These results raise the possibility that microglia may play a fundamental role in the pathogenesis of amyloid deposition in the cerebellum in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)493-498
Number of pages6
JournalActa Neuropathologica
Volume80
Issue number5
DOIs
StatePublished - Sep 1990
Externally publishedYes

Fingerprint

Amyloid Plaques
Microglia
Alzheimer Disease
Cerebellum
CD45 Antigens
HLA-DR Antigens
Amyloid
Immunohistochemistry
Antibodies

Keywords

  • Alzheimer's disease
  • Amyloid
  • HLA-DR
  • Microglia
  • Senile plaque

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Microglia in cerebellar plaques in Alzheimer's disease. / Mattiace, L. A.; Davies, P.; Yen, S. H.; Dickson, Dennis W.

In: Acta Neuropathologica, Vol. 80, No. 5, 09.1990, p. 493-498.

Research output: Contribution to journalArticle

Mattiace, L. A. ; Davies, P. ; Yen, S. H. ; Dickson, Dennis W. / Microglia in cerebellar plaques in Alzheimer's disease. In: Acta Neuropathologica. 1990 ; Vol. 80, No. 5. pp. 493-498.
@article{6174aa9e5c0e45f8991a8cd834973e05,
title = "Microglia in cerebellar plaques in Alzheimer's disease",
abstract = "Cerebellar amyloid deposits in Alzheimer's disease were studied by immunocytochemistry and with a series of antibodies that recognize human microglia, including anti-HLA-DR, LN-1, Leu-M5 and leukocyte common antigen. Microglia formed a dense reticular array throughout the cerebellum in areas with and without amyloid deposits. In areas with compact and reticular amyloid deposits, microglia had morphological features consistent with activation, such as cytoplasmic swelling and shortening and thickening of cell processes. In areas with diffuse amyloid deposits, microglia had delicate and highly ramified processes. Nevertheless, microglial cells or their processes were detected in association with amyloid deposits of all morphological types. These results raise the possibility that microglia may play a fundamental role in the pathogenesis of amyloid deposition in the cerebellum in Alzheimer's disease.",
keywords = "Alzheimer's disease, Amyloid, HLA-DR, Microglia, Senile plaque",
author = "Mattiace, {L. A.} and P. Davies and Yen, {S. H.} and Dickson, {Dennis W}",
year = "1990",
month = "9",
doi = "10.1007/BF00294609",
language = "English (US)",
volume = "80",
pages = "493--498",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Microglia in cerebellar plaques in Alzheimer's disease

AU - Mattiace, L. A.

AU - Davies, P.

AU - Yen, S. H.

AU - Dickson, Dennis W

PY - 1990/9

Y1 - 1990/9

N2 - Cerebellar amyloid deposits in Alzheimer's disease were studied by immunocytochemistry and with a series of antibodies that recognize human microglia, including anti-HLA-DR, LN-1, Leu-M5 and leukocyte common antigen. Microglia formed a dense reticular array throughout the cerebellum in areas with and without amyloid deposits. In areas with compact and reticular amyloid deposits, microglia had morphological features consistent with activation, such as cytoplasmic swelling and shortening and thickening of cell processes. In areas with diffuse amyloid deposits, microglia had delicate and highly ramified processes. Nevertheless, microglial cells or their processes were detected in association with amyloid deposits of all morphological types. These results raise the possibility that microglia may play a fundamental role in the pathogenesis of amyloid deposition in the cerebellum in Alzheimer's disease.

AB - Cerebellar amyloid deposits in Alzheimer's disease were studied by immunocytochemistry and with a series of antibodies that recognize human microglia, including anti-HLA-DR, LN-1, Leu-M5 and leukocyte common antigen. Microglia formed a dense reticular array throughout the cerebellum in areas with and without amyloid deposits. In areas with compact and reticular amyloid deposits, microglia had morphological features consistent with activation, such as cytoplasmic swelling and shortening and thickening of cell processes. In areas with diffuse amyloid deposits, microglia had delicate and highly ramified processes. Nevertheless, microglial cells or their processes were detected in association with amyloid deposits of all morphological types. These results raise the possibility that microglia may play a fundamental role in the pathogenesis of amyloid deposition in the cerebellum in Alzheimer's disease.

KW - Alzheimer's disease

KW - Amyloid

KW - HLA-DR

KW - Microglia

KW - Senile plaque

UR - http://www.scopus.com/inward/record.url?scp=0024992306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024992306&partnerID=8YFLogxK

U2 - 10.1007/BF00294609

DO - 10.1007/BF00294609

M3 - Article

C2 - 2251906

AN - SCOPUS:0024992306

VL - 80

SP - 493

EP - 498

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 5

ER -