Microfluidic co-cultures with hydrogel-based ligand trap to study paracrine signals giving rise to cancer drug resistance

Engineering & Materials Science

• Cells 35%
• Drug Delivery Systems 26%
• Fibroblasts 52%
• Gels 37%
• Hydrogels 70%
• Intercellular Signaling Peptides and Proteins 82%
• Ligands 72%
• Microfluidics 57%

Medicine & Life Sciences

• Coculture Techniques 54%
• Conditioned Culture Medium 6%
• Drug Delivery Systems 6%
• Drug Resistance 49%
• Equipment and Supplies 4%
• Fibroblast Growth Factor 2 14%
• Gels 11%
• Hydrogels 58%
• Intercellular Signaling Peptides and Proteins 5%
• Ligands 38%
• Melanoma 16%
• Microfluidics 65%
• Mutation 3%
• Neoplasms 17%
• Therapeutics 2%
• Tumor Microenvironment 14%
• Vemurafenib 59%

Chemical Compounds

• Conditioned Culture Medium 16%
• Drug 5%
• Gel 13%
• Growth Factor 12%
• Hydrogel 8%
• Mutation 9%
• Probe 6%
• Resistance 20%
• Vemurafenib 100%