Microbial induction of vascular pathology in the CNS

Sylvia Kang, Dorian B. McGavern

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

The central nervous system (CNS) is a finely tuned organ that participates in nearly every aspect of our day-to-day function. Neurons lie at the core of this functional unit and maintain an active dialogue with one another as well as their fellow CNS residents (e.g. astrocytes, oligodendrocytes, microglia). Because of this complex dialogue, it is essential that the CNS milieu be tightly regulated in order to permit uninterrupted and efficient neural chemistry. This is accomplished in part by anatomical barriers that segregate vascular components from the cerebral spinal fluid (CSF) and brain parenchyma. These barriers impede entry of noxious materials and enable the CNS to maintain requisite protein and ionic balances for constant electrochemical signaling. Under homeostatic conditions, the CNS is protected by the presence of specialized endothelium/epithelium, the blood brain barrier (BBB), and the blood-CSF barrier. However, following CNS infection these protective barriers can be comprised, sometimes resulting in severe neurological complications triggered by an imbalance or blockage of neural chemistry. In some instances, these disruptions are severe enough to be fatal. This review focuses on a selection of microbes (both viruses and parasites) that compromise vascular barriers and induce neurological complications upon gaining access to the CNS. Emphasis is placed on CNS diseases that result from a pathogenic interplay between host immune defenses and the invading microbe.

Original languageEnglish (US)
Pages (from-to)370-386
Number of pages17
JournalJournal of NeuroImmune Pharmacology
Volume5
Issue number3
DOIs
StatePublished - Sep 2010
Externally publishedYes

Fingerprint

Blood Vessels
Central Nervous System
Pathology
Central Nervous System Infections
Central Nervous System Diseases
Oligodendroglia
Microglia
Blood-Brain Barrier
Astrocytes
Endothelium
Parasites
Epithelium
Viruses
Neurons
Brain
Proteins

Keywords

  • blood brain barrier
  • blood vessel
  • brain
  • cerebral spinal fluid
  • Dengue virus
  • Ebola virus
  • hemorrhagic fevers
  • Lassa fever virus
  • LCMV
  • malaria
  • monocytes
  • neutrophils
  • T cells
  • Theiler's virus
  • vasculature
  • ventricles

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Microbial induction of vascular pathology in the CNS. / Kang, Sylvia; McGavern, Dorian B.

In: Journal of NeuroImmune Pharmacology, Vol. 5, No. 3, 09.2010, p. 370-386.

Research output: Contribution to journalReview article

Kang, Sylvia ; McGavern, Dorian B. / Microbial induction of vascular pathology in the CNS. In: Journal of NeuroImmune Pharmacology. 2010 ; Vol. 5, No. 3. pp. 370-386.
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