Micro-CT imaging of structure-to-function relationship of bone microstructure and associated vascular involvement

E. L. Ritman, M. E. Bolander, L. A. Fitzpatrick, R. T. Turner

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

We are exploring methods of quantitating the 3D microstructure of bone in a way that will provide quantitative information about the functional status of the bone. The basic strategy is to image the spatial distribution of a selected, local, marker of function (e.g, material properties or new bone formation) and relate this to the simultaneously imaged 3D anatomic microstructure. Many of these approaches are extensions of well-established 2D imaging techniques (e.g., use of fluorophores and autoradiography) to 3D micro-CT. Local stresses throughout the microstructure can be estimated from the 3D geometry (and change in that geometry in response to stress applied to the outside of the bones) and correlated to the local function. In addition to study of bone, we are also exploring calcification of arterial walls, both within the hone and outside the bone, such as coronary arteries. Arterial calcification in ovariectomised rats has been observed.

Original languageEnglish (US)
Pages (from-to)403-412
Number of pages10
JournalTechnology and Health Care
Volume6
Issue number5-6
StatePublished - Dec 1 1998

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Keywords

  • Osteoclast
  • Torsion
  • Vascular calcification

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Information Systems
  • Biomedical Engineering
  • Health Informatics

Cite this

Ritman, E. L., Bolander, M. E., Fitzpatrick, L. A., & Turner, R. T. (1998). Micro-CT imaging of structure-to-function relationship of bone microstructure and associated vascular involvement. Technology and Health Care, 6(5-6), 403-412.