Abstract
The recent rapid increase in interest in tomographic imaging of small animals and of human (and large animal) organ biopsies is driven largely by drug discovery, cancer detection/monitoring, phenotype identification and/or characterization, and development of disease detection methods and monitoring efficacies of drugs in disease treatment. In biomedical applications, micro-computed tomography (CT) scanners can function as scaled-down (i.e., mini) clinical CT scanners that provide a three-dimensional (3-D) image of most, if not the entire, torso of a mouse at image resolution (50-100 μm) scaled proportional to that of a human CT image. Micro-CT scanners, on the other hand, image specimens the size of intact rodent organs at spatial resolutions from cellular (20 μm) down to subcellular dimensions (e.g., 1 μm) and fill the resolution-hiatus between microscope imaging, which resolves individual cells in thin sections of tissue, and mini-CT imaging of intact volumes.
Original language | English (US) |
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Pages (from-to) | 185-208 |
Number of pages | 24 |
Journal | Annual Review of Biomedical Engineering |
Volume | 6 |
DOIs | |
State | Published - 2004 |
Keywords
- Contrast agents
- Small animal
- Synchrotron
- Three-dimensional
- X-ray
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Biomedical Engineering