TY - JOUR
T1 - MGUS and smoldering multiple myeloma
T2 - update on pathogenesis, natural history, and management.
AU - Rajkumar, S. Vincent
PY - 2005
Y1 - 2005
N2 - Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic, pre-malignant disorders characterized by monoclonal plasma cell proliferation in the bone marrow and absence of end-organ damage. Recent advances in the pathogenesis, natural history, and prognosis of MGUS and SMM are reviewed. A new risk stratification system to determine the prognosis of MGUS using the size and type of M protein, and the serum free light chain assay is discussed.
AB - Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic, pre-malignant disorders characterized by monoclonal plasma cell proliferation in the bone marrow and absence of end-organ damage. Recent advances in the pathogenesis, natural history, and prognosis of MGUS and SMM are reviewed. A new risk stratification system to determine the prognosis of MGUS using the size and type of M protein, and the serum free light chain assay is discussed.
UR - http://www.scopus.com/inward/record.url?scp=33646420995&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646420995&partnerID=8YFLogxK
U2 - 10.1182/asheducation-2005.1.340
DO - 10.1182/asheducation-2005.1.340
M3 - Article
C2 - 16304401
AN - SCOPUS:33646420995
SN - 1520-4391
SP - 340
EP - 345
JO - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
JF - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
ER -