Metronidazole- and carbapenem-resistant Bacteroides thetaiotaomicron isolated in Rochester, Minnesota, in 2014

Sapna P. Sadarangani, Scott A. Cunningham, Patricio R. Jeraldo, John W. Wilson, Reeti Khare, Robin Patel

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Emerging antimicrobial resistance in members of the Bacteroides fragilis group is a concern in clinical medicine. Although metronidazole and carbapenem resistance have been reported in Bacteroides thetaiotaomicron, a member of the B. fragilis group, they have not, to the best of our knowledge, been reported together in the same B. thetaiotaomicron isolate. Herein, we report isolation of piperacillin-tazobactam-, metronidazole-, clindamycin-, ertapenem-, and meropenem-resistant B. thetaiotaomicron from a patient with postoperative intra-abdominal abscess and empyema. Whole-genome sequencing demonstrated the presence of nimD with at least a portion of IS1169 upstream, a second putative nim gene, two β-lactamase genes (one of which has not been previously reported), two tetX genes, tetQ, ermF, two cat genes, and a number of efflux pumps. This report highlights emerging antimicrobial resistance in B. thetaiotaomicron and the importance of identification and antimicrobial susceptibility testing of selected anaerobic bacteria.

Original languageEnglish (US)
Pages (from-to)4157-4161
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number7
DOIs
StatePublished - Jul 1 2015

Fingerprint

Carbapenems
Metronidazole
Bacteroides fragilis
meropenem
Genes
Abdominal Abscess
Empyema
Anaerobic Bacteria
Clindamycin
Clinical Medicine
Cats
Genome
Bacteroides thetaiotaomicron

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Metronidazole- and carbapenem-resistant Bacteroides thetaiotaomicron isolated in Rochester, Minnesota, in 2014. / Sadarangani, Sapna P.; Cunningham, Scott A.; Jeraldo, Patricio R.; Wilson, John W.; Khare, Reeti; Patel, Robin.

In: Antimicrobial Agents and Chemotherapy, Vol. 59, No. 7, 01.07.2015, p. 4157-4161.

Research output: Contribution to journalArticle

Sadarangani, Sapna P. ; Cunningham, Scott A. ; Jeraldo, Patricio R. ; Wilson, John W. ; Khare, Reeti ; Patel, Robin. / Metronidazole- and carbapenem-resistant Bacteroides thetaiotaomicron isolated in Rochester, Minnesota, in 2014. In: Antimicrobial Agents and Chemotherapy. 2015 ; Vol. 59, No. 7. pp. 4157-4161.
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