Metoclopramide stimulation: A test of growth hormone reserve in adolescent males

H. N. Cohen, Ian D Hay, J. A. Thomson, F. Logue, W. A. Ratcliffe, G. H. Beastall

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A comparison was made between the growth hormone (GH) response to metoclopramide ('Maxolon'-Beecham Laboratories) and insulin induced hypoglycaemia in thirty-five short adolescent males. Both test initially adequate release of GH from the pituitary gland in 86% of those subjects who had normal GH reserve. The peak growth hormone responses of the two tests were similar in magnitude and were strongly correlated (r = 0.80, P < 0.001). Both tests raised serum GH to a similar degree in twenty-nine out of lthe thirty-five boys (83%), but four boys who responded satisfactorily to hypoglycemia failed to respond to metoclopramide (MCP) stimulation, and two boys who failed to respond to hypoglycemia responded satisfactorily to MCP stimulation. MCP stimulation does not require prior preparation of the patient and is relatively free of side effects. Consequently, it is suggested that MCP stimulation may be a useful 1 hour out-patient test for growth hormone deficiency in this relatively common group of patients.

Original languageEnglish (US)
Pages (from-to)89-93
Number of pages5
JournalClinical Endocrinology
Volume11
Issue number1
StatePublished - 1979
Externally publishedYes

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Metoclopramide
Growth Hormone
Hypoglycemia
Pituitary Gland
Outpatients
Insulin
Serum

ASJC Scopus subject areas

  • Endocrinology

Cite this

Cohen, H. N., Hay, I. D., Thomson, J. A., Logue, F., Ratcliffe, W. A., & Beastall, G. H. (1979). Metoclopramide stimulation: A test of growth hormone reserve in adolescent males. Clinical Endocrinology, 11(1), 89-93.

Metoclopramide stimulation : A test of growth hormone reserve in adolescent males. / Cohen, H. N.; Hay, Ian D; Thomson, J. A.; Logue, F.; Ratcliffe, W. A.; Beastall, G. H.

In: Clinical Endocrinology, Vol. 11, No. 1, 1979, p. 89-93.

Research output: Contribution to journalArticle

Cohen, HN, Hay, ID, Thomson, JA, Logue, F, Ratcliffe, WA & Beastall, GH 1979, 'Metoclopramide stimulation: A test of growth hormone reserve in adolescent males', Clinical Endocrinology, vol. 11, no. 1, pp. 89-93.
Cohen HN, Hay ID, Thomson JA, Logue F, Ratcliffe WA, Beastall GH. Metoclopramide stimulation: A test of growth hormone reserve in adolescent males. Clinical Endocrinology. 1979;11(1):89-93.
Cohen, H. N. ; Hay, Ian D ; Thomson, J. A. ; Logue, F. ; Ratcliffe, W. A. ; Beastall, G. H. / Metoclopramide stimulation : A test of growth hormone reserve in adolescent males. In: Clinical Endocrinology. 1979 ; Vol. 11, No. 1. pp. 89-93.
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