METOCLOPRAMIDE STIMULATION: A TEST OF GROWTH HORMONE RESERVE IN ADOLESCENT MALES

H. N. COHEN; I. D. HAY; J. A. THOMSON; F. LOGUE; W. A. RATCLIFFE; G. H. BEASTALL

doi:10.1111/j.1365-2265.1979.tb03050.x

METOCLOPRAMIDE STIMULATION: A TEST OF GROWTH HORMONE RESERVE IN ADOLESCENT MALES

H. N. COHEN, I. D. HAY, J. A. THOMSON, F. LOGUE, W. A. RATCLIFFE, G. H. BEASTALL

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A comparison was made between the growth hormone (GH) response to meto‐clopramide (‘Maxolon’‐Beecham Laboratories) and insulin induced hypoglycaemia in thirty‐five short adolescent males. Both tests initially caused adequate release of GH from the pituitary gland in 86% of those subjects who had normal GH reserve. The peak growth hormone responses of the two tests were similar in magnitude and were strongly correlated (r = 0.80, P < 0.001). Both tests raised serum GH to a similar degree in twenty‐nine out of the thirty‐five boys (83%), but four boys who responded satisfactorily to hypoglycaemia failed to respond to metoclopramide (MCP) stimulation, and two boys who failed to respond to hypoglycaemia responded satisfactorily to MCP stimulation. MCP stimulation does not require prior preparation of the patient and is relatively free of side effects. Consequently, it is suggested that MCP stimulation may be a useful 1 hour out‐patient test for growth hormone deficiency in this relatively common group of patients.

Original language	English (US)
Pages (from-to)	89-93
Number of pages	5
Journal	Clinical Endocrinology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2265.1979.tb03050.x
State	Published - Jul 1979

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1111/j.1365-2265.1979.tb03050.x

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abstract = "A comparison was made between the growth hormone (GH) response to meto‐clopramide ({\textquoteleft}Maxolon{\textquoteright}‐Beecham Laboratories) and insulin induced hypoglycaemia in thirty‐five short adolescent males. Both tests initially caused adequate release of GH from the pituitary gland in 86% of those subjects who had normal GH reserve. The peak growth hormone responses of the two tests were similar in magnitude and were strongly correlated (r = 0.80, P < 0.001). Both tests raised serum GH to a similar degree in twenty‐nine out of the thirty‐five boys (83%), but four boys who responded satisfactorily to hypoglycaemia failed to respond to metoclopramide (MCP) stimulation, and two boys who failed to respond to hypoglycaemia responded satisfactorily to MCP stimulation. MCP stimulation does not require prior preparation of the patient and is relatively free of side effects. Consequently, it is suggested that MCP stimulation may be a useful 1 hour out‐patient test for growth hormone deficiency in this relatively common group of patients.",

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AU - RATCLIFFE, W. A.

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AB - A comparison was made between the growth hormone (GH) response to meto‐clopramide (‘Maxolon’‐Beecham Laboratories) and insulin induced hypoglycaemia in thirty‐five short adolescent males. Both tests initially caused adequate release of GH from the pituitary gland in 86% of those subjects who had normal GH reserve. The peak growth hormone responses of the two tests were similar in magnitude and were strongly correlated (r = 0.80, P < 0.001). Both tests raised serum GH to a similar degree in twenty‐nine out of the thirty‐five boys (83%), but four boys who responded satisfactorily to hypoglycaemia failed to respond to metoclopramide (MCP) stimulation, and two boys who failed to respond to hypoglycaemia responded satisfactorily to MCP stimulation. MCP stimulation does not require prior preparation of the patient and is relatively free of side effects. Consequently, it is suggested that MCP stimulation may be a useful 1 hour out‐patient test for growth hormone deficiency in this relatively common group of patients.

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METOCLOPRAMIDE STIMULATION: A TEST OF GROWTH HORMONE RESERVE IN ADOLESCENT MALES

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