Protein domains of the Royal Family were the first methyllysine binding domains to be discovered. Here, we review what was learned from the structural studies of Royal Family members including chromo, Tudor, MBT, chromo barrel, and PWWP domains. Our main focus is on methyllysine reader domains for which three-dimensional structures are available in the ligand-bound state.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)