Methotrexate-induced and Epstein-Barr virus-associated B-cell lymphoma of the spine: MR and PET/CT imaging

Ba D. Nguyen; Michael C. Roarke; Ann E. McCullough

doi:10.1097/RLU.0b013e318162db78

Methotrexate-induced and Epstein-Barr virus-associated B-cell lymphoma of the spine: MR and PET/CT imaging

Ba D. Nguyen, Michael C. Roarke, Ann E. McCullough

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Methotrexate, used as a disease-modifying agent in the treatment of rheumatoid arthritis and other connective tissue diseases, may depress the immune system and increase the already high risk of Epstein-Barr virus infection in this immune-challenged patient population. The combined impact of methotrexate and Epstein-Barr virus may induce lymphoproliferative disorders involving skin, lung, nodes and central nervous system. The authors present a case of dermatomyositis with methotrexate-related and Epstein-Barr-associated thoracic spinal and paraspinal diffuse large B-cell lymphoma.

Original language	English (US)
Pages (from-to)	208-210
Number of pages	3
Journal	Clinical nuclear medicine
Volume	33
Issue number	3
DOIs	https://doi.org/10.1097/RLU.0b013e318162db78
State	Published - Mar 2008

Keywords

B-cell lymphoma
Epstein-Barr virus
Magnetic resonance imaging
Methotrexate
Positron emission tomography
Spine

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1097/RLU.0b013e318162db78

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abstract = "Methotrexate, used as a disease-modifying agent in the treatment of rheumatoid arthritis and other connective tissue diseases, may depress the immune system and increase the already high risk of Epstein-Barr virus infection in this immune-challenged patient population. The combined impact of methotrexate and Epstein-Barr virus may induce lymphoproliferative disorders involving skin, lung, nodes and central nervous system. The authors present a case of dermatomyositis with methotrexate-related and Epstein-Barr-associated thoracic spinal and paraspinal diffuse large B-cell lymphoma.",

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AU - Roarke, Michael C.

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AB - Methotrexate, used as a disease-modifying agent in the treatment of rheumatoid arthritis and other connective tissue diseases, may depress the immune system and increase the already high risk of Epstein-Barr virus infection in this immune-challenged patient population. The combined impact of methotrexate and Epstein-Barr virus may induce lymphoproliferative disorders involving skin, lung, nodes and central nervous system. The authors present a case of dermatomyositis with methotrexate-related and Epstein-Barr-associated thoracic spinal and paraspinal diffuse large B-cell lymphoma.

KW - B-cell lymphoma

KW - Epstein-Barr virus

KW - Magnetic resonance imaging

KW - Methotrexate

KW - Positron emission tomography

KW - Spine

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Methotrexate-induced and Epstein-Barr virus-associated B-cell lymphoma of the spine: MR and PET/CT imaging

Abstract

Keywords

ASJC Scopus subject areas

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