Methotrexate-induced and Epstein-Barr virus-associated B-cell lymphoma of the spine: MR and PET/CT imaging

Ba D. Nguyen, Michael C. Roarke, Ann E. McCullough

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Methotrexate, used as a disease-modifying agent in the treatment of rheumatoid arthritis and other connective tissue diseases, may depress the immune system and increase the already high risk of Epstein-Barr virus infection in this immune-challenged patient population. The combined impact of methotrexate and Epstein-Barr virus may induce lymphoproliferative disorders involving skin, lung, nodes and central nervous system. The authors present a case of dermatomyositis with methotrexate-related and Epstein-Barr-associated thoracic spinal and paraspinal diffuse large B-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)208-210
Number of pages3
JournalClinical nuclear medicine
Volume33
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • B-cell lymphoma
  • Epstein-Barr virus
  • Magnetic resonance imaging
  • Methotrexate
  • Positron emission tomography
  • Spine

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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