Methodology of a multispecialty outpatient Obesity Treatment Research Program

Dalia S. Mikhail, Teresa B. Jensen, Todd W. Wade, Jane F. Myers, Jennifer M. Frank, Mark L. Wieland, Don Hensrud, M. Molly McMahon, Maria L. Collazo-Clavell, Haitham Abu-Lebdeh, Kurt A. Kennel, Daniel L. Hurley, Karen Grothe, Michael Dennis Jensen

Research output: Contribution to journalArticle

1 Scopus citations


Despite the large number of U.S. adults who overweight or obese, few providers have ready access to comprehensive lifestyle interventions, the cornerstone of medical obesity management. Our goal was to establish a research infrastructure embedded in a comprehensive lifestyle intervention treatment for obesity. The Obesity Treatment Research Program (OTRP) is a multi-specialty project at Mayo Clinic in Rochester, Minnesota designed to provide a high intensity, year-long, comprehensive lifestyle obesity treatment. The program includes a nutritional intervention designed to reduce energy intake, a physical activity program and a cognitive behavioral approach to increase the likelihood of long-term adherence. The behavioral intervention template incorporated the Diabetes Prevention Program and the Look AHEAD trial materials. The OTRP is consistent with national recommendations for the management of overweight and obesity in adults, but with embedded features designed to identify patient characteristics that might help predict outcomes, assure long-term follow up and support various research initiatives. Our goal was to develop approaches to understand whether there are patient characteristics that predict treatment outcomes.

Original languageEnglish (US)
Pages (from-to)36-41
Number of pages6
JournalContemporary Clinical Trials Communications
StatePublished - Jun 1 2018



  • Exercise prescription
  • Individualized obesity treatment
  • Intensive lifestyle intervention
  • Intensive lifestyle program
  • Obesity
  • Weight loss

ASJC Scopus subject areas

  • Pharmacology

Cite this

Mikhail, D. S., Jensen, T. B., Wade, T. W., Myers, J. F., Frank, J. M., Wieland, M. L., Hensrud, D., McMahon, M. M., Collazo-Clavell, M. L., Abu-Lebdeh, H., Kennel, K. A., Hurley, D. L., Grothe, K., & Jensen, M. D. (2018). Methodology of a multispecialty outpatient Obesity Treatment Research Program. Contemporary Clinical Trials Communications, 10, 36-41.