Methodology for the Guidelines on Evaluation and Management of Hypoparathyroidism and Primary Hyperparathyroidism

Liang Yao, Gordon Guyatt, Zhikang Ye, John P. Bilezikian, Maria Luisa Brandi, Bart L. Clarke, Michael Mannstadt, Aliya A. Khan

Research output: Contribution to journalArticlepeer-review

Abstract

To develop guidelines for hypoparathyroidism and primary hyperparathyroidism, the panel assembled a panel of experts in parathyroid disorders, general endocrinologists, representatives of the Hypoparathyroidism Association, and systematic review and guideline methodologists. The guideline panel referred to a formal process following the Recommendations, Assessment, Development, and Evaluation Working Group (GRADE) methodology to issue GRADEd recommendations. In this approach, panelists and methodologists formatted the questions, conducted systematic reviews, evaluated risk of bias, assessed certainty of evidence, and presented a summary of findings in a transparent fashion. For most recommendations, the task forces used a less structured approach largely based on narrative reviews to issue non-GRADEd recommendations. The panel issued Eight GRADEd recommendations (seven for hypoparathyroidism and one for hyperparathyroidism). Each GRADEd recommendation is linked to the underlying body of evidence and judgments regarding the certainty of evidence and strength of recommendations, values and preferences, and costs, feasibility, acceptability and equity. This article summarizes the methodology for issuing GRADEd and non-GRADEd recommendations for patients with hypoparathyroidism or hyperparathyroidism.

Original languageEnglish (US)
Pages (from-to)2404-2410
Number of pages7
JournalJournal of Bone and Mineral Research
Volume37
Issue number11
DOIs
StatePublished - Nov 2022

Keywords

  • DISORDERS OF CALCIUM/PHOSPHATE METABOLISM
  • EPIDEMIOLOGY
  • HEALTH SERVICES RESEARCH
  • HORMONE REPLACEMENT/RECEPTOR MODULATORS
  • PARATHYROID-RELATED DISORDERS
  • THERAPEUTICS

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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