The high uncertainty of the emergency department (ED) and intermittent time-critical activities creates unpredictable staff workloads. Frequent interruptions are inherent to this acute care work environment adding to the demands placed on clinicians. Implementing sustainable interventions to mitigate interruptions has been a challenge. This study examined interruptions in the emergency department and provides a methodology for co-creating interventions to eliminate and/or manage interruptions impact on the care process. Observers collected and categorized interruptions using a validated tablet PC-based tool during clinicians' entire shifts. Focus groups were used to develop and select provider-centered interventions. A total of 7889 interruptions were identified across 91 shifts. A total of 24 interventions were selected for potential implementation. The interventions were related to (1) protocol, procedures and policy, (2) information sharing, (3) devices and (4) role clarity. Developing sustainable solutions to interruptions has the potential to reduce patients' vulnerability.