Methicillin-resistant Staphylococcus aureus infections in ICU patients

Ramachandra Sista, Gina Oda, Juliana Barr

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

The incidence of MRSA infections in ICU patients is growing at an alarming rate, with an associated increase in morbidity and mortality, and the costs of caring for these patients. The antibiotic choices that are currently available for treating patients with MRSA infections are both limited and expensive, and there is growing evidence of resistance by S aureus to both vancomycin and dalfopristin-quinopristin. Although widespread inappropriate antibiotic use has contributed to the growing emergence of MRSA in the ICU and elsewhere, horizontal transmission remains the primary mechanism by which patients become colonized or infected with MRSA. The increasing number of MRSA-positive patients being admitted to the ICU, together with frequent contact with these patients by ICU staff and visitors alike, has contributed to the disproportional increase in the incidence of MRSA in the ICU compared with other inpatient areas of the hospital. Prevention control measures including surveillance culturing of all ICU patients, rigorous handwashing practices, contact isolation precautions, and rational antibiotic use are the best methods for reducing the spread of MRSA in the ICU.

Original languageEnglish (US)
Pages (from-to)405-435
Number of pages31
JournalAnesthesiology Clinics of North America
Volume22
Issue number3
DOIs
StatePublished - Sep 2004

Fingerprint

Methicillin-Resistant Staphylococcus aureus
Infection
Anti-Bacterial Agents
Hand Disinfection
Incidence
Vancomycin
Inpatients
Morbidity
Costs and Cost Analysis
Mortality

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Methicillin-resistant Staphylococcus aureus infections in ICU patients. / Sista, Ramachandra; Oda, Gina; Barr, Juliana.

In: Anesthesiology Clinics of North America, Vol. 22, No. 3, 09.2004, p. 405-435.

Research output: Contribution to journalReview article

@article{6a960e19768941afb1bdc092b75c5e99,
title = "Methicillin-resistant Staphylococcus aureus infections in ICU patients",
abstract = "The incidence of MRSA infections in ICU patients is growing at an alarming rate, with an associated increase in morbidity and mortality, and the costs of caring for these patients. The antibiotic choices that are currently available for treating patients with MRSA infections are both limited and expensive, and there is growing evidence of resistance by S aureus to both vancomycin and dalfopristin-quinopristin. Although widespread inappropriate antibiotic use has contributed to the growing emergence of MRSA in the ICU and elsewhere, horizontal transmission remains the primary mechanism by which patients become colonized or infected with MRSA. The increasing number of MRSA-positive patients being admitted to the ICU, together with frequent contact with these patients by ICU staff and visitors alike, has contributed to the disproportional increase in the incidence of MRSA in the ICU compared with other inpatient areas of the hospital. Prevention control measures including surveillance culturing of all ICU patients, rigorous handwashing practices, contact isolation precautions, and rational antibiotic use are the best methods for reducing the spread of MRSA in the ICU.",
author = "Ramachandra Sista and Gina Oda and Juliana Barr",
year = "2004",
month = "9",
doi = "10.1016/j.atc.2004.04.006",
language = "English (US)",
volume = "22",
pages = "405--435",
journal = "Anesthesiology Clinics of North America",
issn = "0889-8537",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Methicillin-resistant Staphylococcus aureus infections in ICU patients

AU - Sista, Ramachandra

AU - Oda, Gina

AU - Barr, Juliana

PY - 2004/9

Y1 - 2004/9

N2 - The incidence of MRSA infections in ICU patients is growing at an alarming rate, with an associated increase in morbidity and mortality, and the costs of caring for these patients. The antibiotic choices that are currently available for treating patients with MRSA infections are both limited and expensive, and there is growing evidence of resistance by S aureus to both vancomycin and dalfopristin-quinopristin. Although widespread inappropriate antibiotic use has contributed to the growing emergence of MRSA in the ICU and elsewhere, horizontal transmission remains the primary mechanism by which patients become colonized or infected with MRSA. The increasing number of MRSA-positive patients being admitted to the ICU, together with frequent contact with these patients by ICU staff and visitors alike, has contributed to the disproportional increase in the incidence of MRSA in the ICU compared with other inpatient areas of the hospital. Prevention control measures including surveillance culturing of all ICU patients, rigorous handwashing practices, contact isolation precautions, and rational antibiotic use are the best methods for reducing the spread of MRSA in the ICU.

AB - The incidence of MRSA infections in ICU patients is growing at an alarming rate, with an associated increase in morbidity and mortality, and the costs of caring for these patients. The antibiotic choices that are currently available for treating patients with MRSA infections are both limited and expensive, and there is growing evidence of resistance by S aureus to both vancomycin and dalfopristin-quinopristin. Although widespread inappropriate antibiotic use has contributed to the growing emergence of MRSA in the ICU and elsewhere, horizontal transmission remains the primary mechanism by which patients become colonized or infected with MRSA. The increasing number of MRSA-positive patients being admitted to the ICU, together with frequent contact with these patients by ICU staff and visitors alike, has contributed to the disproportional increase in the incidence of MRSA in the ICU compared with other inpatient areas of the hospital. Prevention control measures including surveillance culturing of all ICU patients, rigorous handwashing practices, contact isolation precautions, and rational antibiotic use are the best methods for reducing the spread of MRSA in the ICU.

UR - http://www.scopus.com/inward/record.url?scp=4344602968&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4344602968&partnerID=8YFLogxK

U2 - 10.1016/j.atc.2004.04.006

DO - 10.1016/j.atc.2004.04.006

M3 - Review article

C2 - 15325711

AN - SCOPUS:4344602968

VL - 22

SP - 405

EP - 435

JO - Anesthesiology Clinics of North America

JF - Anesthesiology Clinics of North America

SN - 0889-8537

IS - 3

ER -