Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells

Mamatha Bhat, Akiko Yanagiya, Tyson Graber, Nataliya Razumilava, Steve Bronk, Domenick Zammit, Yunhao Zhao, Chadi Zakaria, Peter Metrakos, Michael Pollak, Nahum Sonenberg, Gregory James Gores, Maritza Jaramillo, Masahiro Morita, Tommy Alain

Research output: Contribution to journalArticle

12 Scopus citations
Original languageEnglish (US)
Pages (from-to)50542-50556
Number of pages15
JournalOncotarget
Volume8
Issue number31
DOIs
StatePublished - Feb 7 2017

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Keywords

  • 4E-BPs
  • Hepatocellular carcinoma
  • Metformin
  • MRNA translation
  • MTORC1

ASJC Scopus subject areas

  • Oncology

Cite this

Bhat, M., Yanagiya, A., Graber, T., Razumilava, N., Bronk, S., Zammit, D., Zhao, Y., Zakaria, C., Metrakos, P., Pollak, M., Sonenberg, N., Gores, G. J., Jaramillo, M., Morita, M., & Alain, T. (2017). Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells. Oncotarget, 8(31), 50542-50556. https://doi.org/10.18632/oncotarget.10671