Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells

Ameet K. Mishra, David Dingli

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

IL-6 signaling plays a crucial role in the pathogenesis of a number of diseases, including multiple myeloma, primary amyloidosis, cytokine release syndrome and other inflammatory conditions. It is central for the growth and survival of malignant plasma cells. IL-6R and IL-6ST receptors transduce IL-6 signaling. Molecular mechanisms regulating expression of IL-6R are not well understood and current therapies are based on monoclonal antibody to target IL-6 signaling. Small molecule inhibitors targeting IL-6 signaling are highly desirable. Metformin specifically decreased IL-6R expression which is mediated via AMPK, mTOR, and miR34a. This is a novel finding and adds to existing therapies targeting IL-6 signaling.

Original languageEnglish (US)
Pages (from-to)2695-2709
Number of pages15
JournalLeukemia
Volume33
Issue number11
DOIs
StatePublished - Nov 1 2019

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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