Metastatisch bedingte Rückenmarkskompression

Ein validierter Überlebensscore für ältere Patienten

Translated title of the contribution: Metastatic spinal cord compression: A validated survival score for elderly patients

Dirk Rades, Jasmin N. Evers, Amira Bajrovic, Theo Veninga, Johann H. Karstens, Steven E. Schild

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Results: In the multivariate analysis of the test group, age, performance status, primary tumor type, ambulatory status, other bone metastases, visceral metastases, interval from cancer diagnosis to radiotherapy of MSCC, and time to developing motor deficits were significantly associated with survival. Total scores ranged from 25 to 57 points. In the test group, 6-month survival rates were 11 % for 25–39 points, 56 % for 40–48 points, and 97 % for 49–57 points (p < 0.001). In the validation group, 6-month survival rates were 10, 53, and 94 %, respectively (p < 0.001).

Conclusion: Based on the survival scores of the test group, three prognostic groups were identified. The survival rates of the validation group were similar to the test group. This score appears reproducible and can help select the appropriate treatment for elderly patients with MSCC.

Background and purpose: This study aimed to develop a validated survival score for elderly patients with metastatic spinal cord compression (MSCC).

Patients and methods: In all, 1,128 patients were randomly assigned to the test (n = 564) or validation group (n = 564). In the test group, ten pretreatment factors (age, gender, performance status, primary tumor, number of involved vertebrae, ambulatory status, other bone metastases, visceral metastases, interval from cancer diagnosis to radiotherapy of MSCC, time to developing motor deficits) plus the radiation regimen were retrospectively evaluated. Factors significantly associated with survival on multivariate analysis were included in the survival score. The score for each factor was determined by dividing the 6-month survival rate (%) by 10. The prognostic score represented the sum of the scores for each factor.

Original languageGerman
Pages (from-to)919-924
Number of pages6
JournalStrahlentherapie und Onkologie
Volume190
Issue number10
DOIs
StatePublished - Sep 30 2014

Fingerprint

Spinal Cord Compression
Survival Rate
Survival
Neoplasm Metastasis
Neoplasms
Radiotherapy
Multivariate Analysis
Bone and Bones
Age Factors
Spine
Age Groups
Radiation

Keywords

  • Elderly patients
  • Metastatic spinal cord compression
  • Prognostic factors
  • Score
  • Survival

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology
  • Medicine(all)

Cite this

Metastatisch bedingte Rückenmarkskompression : Ein validierter Überlebensscore für ältere Patienten. / Rades, Dirk; Evers, Jasmin N.; Bajrovic, Amira; Veninga, Theo; Karstens, Johann H.; Schild, Steven E.

In: Strahlentherapie und Onkologie, Vol. 190, No. 10, 30.09.2014, p. 919-924.

Research output: Contribution to journalArticle

Rades, Dirk ; Evers, Jasmin N. ; Bajrovic, Amira ; Veninga, Theo ; Karstens, Johann H. ; Schild, Steven E. / Metastatisch bedingte Rückenmarkskompression : Ein validierter Überlebensscore für ältere Patienten. In: Strahlentherapie und Onkologie. 2014 ; Vol. 190, No. 10. pp. 919-924.
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AU - Bajrovic, Amira

AU - Veninga, Theo

AU - Karstens, Johann H.

AU - Schild, Steven E.

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AB - Results: In the multivariate analysis of the test group, age, performance status, primary tumor type, ambulatory status, other bone metastases, visceral metastases, interval from cancer diagnosis to radiotherapy of MSCC, and time to developing motor deficits were significantly associated with survival. Total scores ranged from 25 to 57 points. In the test group, 6-month survival rates were 11 % for 25–39 points, 56 % for 40–48 points, and 97 % for 49–57 points (p < 0.001). In the validation group, 6-month survival rates were 10, 53, and 94 %, respectively (p < 0.001).Conclusion: Based on the survival scores of the test group, three prognostic groups were identified. The survival rates of the validation group were similar to the test group. This score appears reproducible and can help select the appropriate treatment for elderly patients with MSCC.Background and purpose: This study aimed to develop a validated survival score for elderly patients with metastatic spinal cord compression (MSCC).Patients and methods: In all, 1,128 patients were randomly assigned to the test (n = 564) or validation group (n = 564). In the test group, ten pretreatment factors (age, gender, performance status, primary tumor, number of involved vertebrae, ambulatory status, other bone metastases, visceral metastases, interval from cancer diagnosis to radiotherapy of MSCC, time to developing motor deficits) plus the radiation regimen were retrospectively evaluated. Factors significantly associated with survival on multivariate analysis were included in the survival score. The score for each factor was determined by dividing the 6-month survival rate (%) by 10. The prognostic score represented the sum of the scores for each factor.

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