Metastatic carcinoid tumors - Are we making the cut?

Kathryn E. Coan, Richard J. Gray, Richard T. Schlinkert, Barbara A. Pockaj, Nabil Wasif

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background: Although controversial, surgical resection for metastatic carcinoid tumors (MCTs) can potentially prolong survival. Methods: Patients with MCTs were identified from the Surveillance, Epidemiology and End Results database. Patients undergoing surgery were compared to unresected patients. Results: Surgery was performed in 33% of patients. Predictors of surgery included age <50 years (odds ratio [OR], 2.4), low grade (OR, 3.1), and the appendix (OR, 36.2) or small intestine (OR, 27.2) as the primary site. Predictors of adverse survival included high grade (hazard ratio, 2.4) and no surgery (hazard ratio, 2.5) or surgery on only primary or distant disease (hazard ratio, 1.5) compared with surgery for both. Survival at 5 years was 5% with no surgery, 28% with surgery on either site, and 46% with surgery at both sites (P <.001). Conclusions: Surgery for MCTs is more common in younger patients, those with low-grade disease, and those with small bowel or appendiceal primary tumors. Although selection bias cannot be excluded, these data lend support to "debulking" for MCT.

Original languageEnglish (US)
Pages (from-to)642-646
Number of pages5
JournalAmerican journal of surgery
Volume205
Issue number6
DOIs
StatePublished - Jun 1 2013

Keywords

  • Carcinoid tumors
  • Metastases
  • Surgery

ASJC Scopus subject areas

  • Surgery

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